Restless legs syndrome

Restless legs syndrome is a common sleep disorder, and studies implicate a genetic basis and thus an inherited tendency to develop the disorder. SNPs in at least five chromosomal regions, including MEIS1/rs2300478, have been reported to be associated with increased risk for restless legs syndrome. [PMID 17637780, PMID 18660810]

Note: the name for this disorder is in the process of changing to Willis-Ekbom disease.[1]

The chromosomal regions mentioned in connection with restless legs syndrome include:

• The MEIS1 gene region on chromosome 2p, including SNPs:
  • rs6710341
  • rs12469063
  • rs2300478

• The BTBD9 gene region on chromosome 6p, including SNPs:
  • rs9394492
  • rs4714156
  • rs9296249
  • rs9357271
  • rs3923809

• A region on chromosome 15q, possibly involving the MAP2K5 gene, including SNPs:
  • rs12593813
  • rs11635424
  • rs884202
  • rs4489954
  • rs3784709
  • rs1026732
  • rs6494696

• A region on chromosome 12q, most likely involving the NOS1 gene, including SNPs:
  • rs7977109

• A 5' untranslated region of the PTPRD gene on chromosome 9, including two independent SNPs:
  • rs4626664
  • rs1975197