rs10086908

plus

Geno	Mag	Summary
(C;C)	2	1.7x increased risk for prostate cancer
(C;T)	2	1.7x increased risk for prostate cancer
(T;T)	0	normal risk

Reference

GRCh38 38.1/141

Chromosome

8

Position

126999692

Gene	LOC105375751

is a	snp
is	mentioned by
dbSNP	rs10086908
dbSNP (classic)	rs10086908
ClinGen	rs10086908
ebi	rs10086908
HLI	rs10086908
Exac	rs10086908
Gnomad	rs10086908
Varsome	rs10086908
LitVar	rs10086908
Map	rs10086908
PheGenI	rs10086908
Biobank	rs10086908
1000 genomes	rs10086908
hgdp	rs10086908
ensembl	rs10086908
geneview	rs10086908
scholar	rs10086908
google	rs10086908
pharmgkb	rs10086908
gwascentral	rs10086908
openSNP	rs10086908
23andMe	rs10086908
SNPshot	rs10086908
SNPdbe	rs10086908
MSV3d	rs10086908
GWAS Ctlg	rs10086908

GMAF

0.2769

Max Magnitude

2

?

(C;C) (C;T) (T;T)

28

rs10086908 is a SNP in the 8q24 chromosomal region, which has been linked in several studies to prostate cancer.

In a study of 1,563 patients of European ancestry, rs10086908 was designated as the representative of a prostate cancer risk region termed "locus 3", with an odds ratio of 1.70 (CI: 1.39-2.07) for carriers of a risk genotype. Two other regions of chromosome 8q24 were also studied.[PMID 17925536]

[PMID 19549807 ] Prostate Cancer Risk Associated Loci in African Americans

[PMID 19767752] Multiple loci on 8q24 associated with prostate cancer susceptibility

[PMID 21756274 ] Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men

[PMID 17978284 ] Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus.

[PMID 18670647 ] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.

[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]

[PMID 24779299] Study of genetic variants of 8q21 and 8q24 associated with prostate cancer in Jing-Jin residents in northern China