rs1041981
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2 | Higher myocardial infarction risk |
| (C;C) | normal |
| Make rs1041981(A;C) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 31573007 |
| Gene | LOC100287329, LTA |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1041981 |
| dbSNP (classic) | rs1041981 |
| ClinGen | rs1041981 |
| ebi | rs1041981 |
| HLI | rs1041981 |
| Exac | rs1041981 |
| Gnomad | rs1041981 |
| Varsome | rs1041981 |
| LitVar | rs1041981 |
| Map | rs1041981 |
| PheGenI | rs1041981 |
| Biobank | rs1041981 |
| 1000 genomes | rs1041981 |
| hgdp | rs1041981 |
| ensembl | rs1041981 |
| geneview | rs1041981 |
| scholar | rs1041981 |
| rs1041981 | |
| pharmgkb | rs1041981 |
| gwascentral | rs1041981 |
| openSNP | rs1041981 |
| 23andMe | rs1041981 |
| SNPshot | rs1041981 |
| SNPdbe | rs1041981 |
| MSV3d | rs1041981 |
| GWAS Ctlg | rs1041981 |
| GMAF | 0.3994 |
| Max Magnitude | 2 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
[PMID 18700950
] 827 males and 709 females, 606 subjects without cancer and 930 subjects with various cancers
- rs1041981(A;C) (C804A, T60N) associated with lung cancer (CA + AA: CC, adjusted OR = 0.60, 95% CI = 0.37 - 0.97),
in males but not in females
[PMID 19167443] Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia
[PMID 20177654] Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians
[PMID 20459604] Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes
[PMID 21291465] The association of genetic polymorphisms with cerebral palsy: a meta-analysis
[PMID 21628868] Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in han chinese
[PMID 22419714] Effect of Type 2 Diabetes Predisposing Genetic Variants on Colorectal Cancer Risk
[PMID 22310064] Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: a pathological study of 1503 consecutive autopsy cases
| ClinVar | |
|---|---|
| Risk | Rs1041981(A;A) |
| Alt | Rs1041981(A;A) |
| Reference | Rs1041981(C;C) |
| Significance | Other |
| Disease | Myocardial infarction |
| Variation | info |
| Gene | LTA |
| CLNDBN | Myocardial infarction |
| Reversed | 0 |
| HGVS | NC_000006.11:g.31540784C>A |
| CLNSRC | OMIM Allelic Variant UniProtKB (protein) |
| CLNACC | RCV000015455.2, |
[PMID 15371359] Testing for Hardy-Weinberg equilibrium in samples with related individuals.
[PMID 16175505] Identification of four gene variants associated with myocardial infarction.
[PMID 16839190] Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.
[PMID 17517687] Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.
[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
[PMID 18398712] No association found between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes.
[PMID 18513389] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
[PMID 18575614] Association between LTA, TNF and AGER polymorphisms and late diabetic complications.
[PMID 18615156] Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
[PMID 18704761] Molecular genetics of myocardial infarction.
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 19585495] Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach.
[PMID 19629486] Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP.
[PMID 20668555] Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.
[PMID 23996684] Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry
[PMID 24587567] Cytokine polymorphisms are associated with poor sleep maintenance in adults living with human immunodeficiency virus/acquired immunodeficiency syndrome
[PMID 24896147] Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans
[PMID 28060727] Associations between genetic variants in immunoregulatory genes and risk of non-Hodgkin lymphoma in a Chinese population.
[PMID 28740106] Environment Changes Genetic Effects on Respiratory Conditions and Allergic Phenotypes.
[PMID 32420584] The effect of LTA gene polymorphisms on cancer risk: An updated systematic review and meta-analysis.
