|(A;A)||1.7||1.7x increased risk that pediatric inhaler use may make asthma worse|
|(A;G)||1.3||1.3x increased risk that pediatric inhaler use may make asthma worse|
A study of 1,182 young Scottish asthma patients (age, 3-22 years) concluded that rs1042713(A) alleles are significantly associated with "exacerbations" of their condition, regardless of treatment regimens (odds ratio 1.30, CI: 1.09-1.55, p=0.003). This didn't hold true for patients using inhalers less than once per day; and it was particularly true for those receiving daily inhaled long- or short-acting beta(2)-agonist treatment (OR, 1.64, CI: 1.22-2.20, p=.001). This may therefore indicate that regular inhalant use of albuterol (found in Ventolin) or long-acting agonists, such as salmeterol found in Advair, may be counter-productive in young asthma patients carrying one or especially two rs1042713(A) alleles.[PMID 19800676]
[PMID 18647184] Association between polymorphisms in the beta2-adrenoceptor gene and migraine in women
[PMID 19553224] Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance
[PMID 20523301] Role of beta(2)-Adrenergic Receptor Polymorphisms on Body Weight and Body Composition Response to Energy Restriction in Obese Women: Preliminary Results
[PMID 20044476] Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runners[PMID 21883537] ?(2) -Adrenergic Receptor Thr164Ile Polymorphism, Blood Pressure and Ischaemic Heart Disease in 66,750 Individuals
|Disease||Asthma Metabolic syndrome salbutamol response - Efficacy salmeterol response - Efficacy|
|CLNDBN||Asthma, nocturnal, susceptibility to Metabolic syndrome, susceptibility to salbutamol response - Efficacy salmeterol response - Efficacy|
|CLNSRC||OMIM Allelic Variant PharmGKB Clinical Annotation|
|CLNACC||RCV000019316.2, RCV000019317.2, RCV000211205.1, RCV000211334.1,|
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[PMID 20167428] Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: results from the 1958 British Birth Cohort Study.
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[PMID 21613201] The effect of maternal and fetal beta2-adrenoceptor and nitric oxide synthase genotype on vasopressor requirement and fetal acid-base status during spinal anesthesia for cesarean delivery.
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[PMID 25682119] Genetic Factors Associated with Exercise Performance in Atmospheric Hypoxia
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