|(C;G)||2.1||normal for bladder cancer risk; 1.9x increased risk for gallbladder cancer|
|(G;G)||2.2||2x increased bladder cancer risk; 4.5x increased risk for gallbladder cancer|
A study of 250 Japanese patients with bladder cancer found an adjusted odds ratio of 2.05 (CI: 1.36-3.08; p = 0.01) for (G;G) homozygotes compared to the other genotypes. In addition, if evaluated only in non-smokers, the adjusted odds ratio increased to 2.78 (CI: 1.39-5.60; p < 0.01).[PMID 18272472]
A study of 200 Chinese patients with gallbladder cancer concluded that increased risk was associated with both the (C;G) genotype (odds ratio 1.9, (CI: = 1.0-3.7) and the (G;G) genotype (odds ratio 4.5, CI: 1.1-22.4).[PMID 17417784]
A study of 300 lung cancer patients of various ethnicities found that the (G;G) genotype was associated with an odds ratio of 2.1 (CI: 1.2-3.7), regardless of sex or ethnicity.[PMID 11927502] However, a Danish study of 400 lung cancer patients found no association.[PMID 17015267]
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