||Normal risk for knee osteoarthritis
||2.3x increased risk for knee osteoarthritis
||3.7x increased risk for knee osteoarthritis
|?|| (C;C) (C;T) (T;T) ||28|
rs10980705, also known as -2820G/A, is a SNP upstream of the lysophosphatidic acid receptor 1 LPAR1 gene.
In a study of 2 Japanese populations of patients with knee osteoarthritis (OA), the rs10980705(T) allele (in dbSNP orientation) was associated with increased risk in two Japanese populations, with an odds ratio of 2.3 (CI: 1.6-3.3, p=2.6x10-5). The association appears to hold only for the homozygous (T;T) genotype, and the authors state they believe this variant may be the "disease-causing SNP". However, 2% of individuals without knee OA are (T;T) homozygotes, and, over 50% of all patients with knee OA are (C;C) homozygotes.[PMID 18325907]
In a study of five collections of samples, and a meta-analysis combining them all, no particularly significant association was seen for rs10980705 with either knee OA or hip OA. These authors conclude it's either a weak effect (and more people need to be studied), or perhaps it's a phenomena more relevant to Asians than to Europeans.[PMID 18625619]
|Desc||LYSOPHOSPHATIDIC ACID RECEPTOR 1; LPAR1|