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rs12329760

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common/normal
Make rs12329760(C;T)
Make rs12329760(T;T)
ReferenceGRCh38 38.1/141
Chromosome21
Position41480570
GeneTMPRSS2
is asnp
is mentioned by
dbSNPrs12329760
dbSNP (old)rs12329760
ClinGenrs12329760
ebirs12329760
HLIrs12329760
Exacrs12329760
Gnomadrs12329760
Varsomers12329760
Maprs12329760
PheGenIrs12329760
Biobankrs12329760
1000 genomesrs12329760
hgdprs12329760
ensemblrs12329760
gopubmedrs12329760
geneviewrs12329760
scholarrs12329760
googlers12329760
pharmgkbrs12329760
gwascentralrs12329760
openSNPrs12329760
23andMers12329760
23andMe allrs12329760
SNPshotrs12329760
SNPdbers12329760
MSV3drs12329760
GWAS Ctlgrs12329760
GMAF0.2897
Max Magnitude0
? (C;C) (C;T) (T;T) 28

news Cases with the TMPRSS2-ERG fusion did not exhibit reduced prostate cancer survival (HR=0.92, 95% CI=0.22-3.93), nor was there a significant difference in cause-specific survival when stratifying by translocation or deletion (HR=0.84, 95% CI=0.23-3.12) or by the number of retained fusion copies (HR=1.22, 95% CI=0.45-3.34). However, evidence for reduced prostate cancer-specific survival was apparent in those cases whose tumor had multiple copies of the fusion.

The variant T allele of the TMPRSS2 SNP, rs12329760, was positively associated with TMPRSS2-ERG fusion by translocation (p=0.05) and with multiple copies of the gene fusion (p=0.03).

Conclusion: If replicated, the results presented here may provide insight into the mechanism by which the TMPRSS2-ERG gene fusion arises and also contribute to diagnostic evaluations for determining the subset of men who will go on to develop metastatic prostate cancer. prostate cancer T allele appears to have lower survival, and higher recurrence.


[PMID 18694509OA-icon.png] Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.