||2x increased risk for meningioma
||1.4x increased risk for meningioma
|?|| (A;A) (A;G) (G;G) ||28|
rs12770228 is a SNP in a region on ch 10p12.31 designated as the chromosome 10 open reading frame 114 C10orf114; it is just upstream of the MLLT10 gene.
A study of ~1,600 patients with meningioma, all of European ancestry, concluded that increased risk for the disease was associated with rs12770228(A) alleles. The odds ratio was 1.37 (CI: 1.18-1.59, p = 4 x 10e-4). A nearby SNP, rs11012732, was also linked to meningioma risk.[PMID 21804547]
[PMID 24755950] Brain tumor risk according to germ-line variation in the MLLT10 locus
[PMID 28405167] Genetic variants and increased risk of meningioma: an updated meta-analysis.