rs1571801
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.5 | >1.36x risk for prostate cancer |
| (A;C) | 1.36x risk for prostate cancer | |
| (C;C) | 0 | average |
| (G;G) | 0 |
| Reference | GRCh38 38.1/142 |
| Chromosome | 9 |
| Position | 121665094 |
| Gene | DAB2IP |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1571801 |
| dbSNP (classic) | rs1571801 |
| ClinGen | rs1571801 |
| ebi | rs1571801 |
| HLI | rs1571801 |
| Exac | rs1571801 |
| Gnomad | rs1571801 |
| Varsome | rs1571801 |
| LitVar | rs1571801 |
| Map | rs1571801 |
| PheGenI | rs1571801 |
| Biobank | rs1571801 |
| 1000 genomes | rs1571801 |
| hgdp | rs1571801 |
| ensembl | rs1571801 |
| geneview | rs1571801 |
| scholar | rs1571801 |
| rs1571801 | |
| pharmgkb | rs1571801 |
| gwascentral | rs1571801 |
| openSNP | rs1571801 |
| 23andMe | rs1571801 |
| SNPshot | rs1571801 |
| SNPdbe | rs1571801 |
| MSV3d | rs1571801 |
| GWAS Ctlg | rs1571801 |
| GMAF | 0.1667 |
| Max Magnitude | 1.5 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
In a study of ~1000 Caucasian patients with prostate cancer, rs1571801 was the SNP most associated with not only prostate cancer, but having an aggressive form of it. The odds ratio for aggressive prostate cancer associated with the risk allele, rs1571801(A), was 1.36 (CI: 1.13 - 1.65, p = 0.001). The odds ratio associated with (nonaggressive) prostate cancer was also higher than average for this SNP; for the same (A) risk allele, it was 1.27 (CI: 1.10 - 1.48, p = 0.0017). [PMID 18073375]
Although the association was found in a study of Caucasian patients, it was also reported to be statistically significant in a population of 210 African-Americans with prostate cancer. [PMID 18073375]
According to [1], "The odds ratio for aggressive prostate cancer ranged from 1.29 to 1.50 in men with one or two copies of the mutant A allele compared with noncarriers."
rs1571801 is located in the DAB2IP gene and encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor.
[PMID 18073375] Associated with aggressive prostate cancer in a study of prostate cancer patients of European descent. Also statistically significant in an African American study population.
[PMID 22046421
] A Common Genetic Variant (97906C>A) of DAB2IP/AIP1 Is Associated with an Increased Risk and Early Onset of Lung Cancer in Chinese Males
[PMID 18794092] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
[PMID 19434657] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
[PMID 19549807] Prostate cancer risk associated loci in African Americans.
[PMID 20039378] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
[PMID 21390317] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
[PMID 21538423] Early onset prostate cancer has a significant genetic component.
[PMID 22077888] Association of prostate cancer risk alleles with unfavourable pathological characteristics in potential candidates for active surveillance.
[PMID 23159463] Genetic sequence variants are associated with severity of lower urinary tract symptoms and prostate cancer susceptibility.
