|(A;A)||1.5||>1.36x risk for prostate cancer|
|(A;C)||1.36x risk for prostate cancer|
In a study of ~1000 Caucasian patients with prostate cancer, rs1571801 was the SNP most associated with not only prostate cancer, but having an aggressive form of it. The odds ratio for aggressive prostate cancer associated with the risk allele, rs1571801(A), was 1.36 (CI: 1.13 - 1.65, p = 0.001). The odds ratio associated with (nonaggressive) prostate cancer was also higher than average for this SNP; for the same (A) risk allele, it was 1.27 (CI: 1.10 - 1.48, p = 0.0017). [PMID 18073375]
Although the association was found in a study of Caucasian patients, it was also reported to be statistically significant in a population of 210 African-Americans with prostate cancer. [PMID 18073375]
According to , "The odds ratio for aggressive prostate cancer ranged from 1.29 to 1.50 in men with one or two copies of the mutant A allele compared with noncarriers."
rs1571801 is located in the DAB2IP gene and encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor.
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