| slightly reduced creatinine clearance |
| Geno
|
Mag
|
Summary
|
| (A;A)
|
2
|
younger, healthier kidney function
|
| (A;G)
|
2
|
younger, healthier kidney function
|
| (G;G)
|
2.4
|
slightly reduced creatinine clearance
|
In the BLSA population, the genotype of rs1711437 explains 2.1% of the variation in creatinine clearance and in the InCHIANTI population, the genotype explains 0.9% of the variation. G is the risk allele. For an individual who carries two copies of the G allele, his or her creatinine clearance is approximately that of someone 4–5 years older who carries no G alleles.
The association between rs1711437 genotype and creatinine clearance has not been replicated in additional populations.
