rs17388568
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.6x risk of type-1 diabetes | |
| (A;G) | 1.3x risk of type-1 diabetes | |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 122408207 |
| Gene | ADAD1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs17388568 |
| dbSNP (classic) | rs17388568 |
| ClinGen | rs17388568 |
| ebi | rs17388568 |
| HLI | rs17388568 |
| Exac | rs17388568 |
| Gnomad | rs17388568 |
| Varsome | rs17388568 |
| LitVar | rs17388568 |
| Map | rs17388568 |
| PheGenI | rs17388568 |
| Biobank | rs17388568 |
| 1000 genomes | rs17388568 |
| hgdp | rs17388568 |
| ensembl | rs17388568 |
| geneview | rs17388568 |
| scholar | rs17388568 |
| rs17388568 | |
| pharmgkb | rs17388568 |
| gwascentral | rs17388568 |
| openSNP | rs17388568 |
| 23andMe | rs17388568 |
| SNPshot | rs17388568 |
| SNPdbe | rs17388568 |
| MSV3d | rs17388568 |
| GWAS Ctlg | rs17388568 |
| GMAF | 0.1726 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs17388568 has been reported in a large study to be associated with type-1 diabetes.
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.26 (CI 1.11-1.42), and for homozygotes, 1.58 (CI 1.27-1.95). [PMID 17554300
]
In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.11 (CI 1.05–1.18). [PMID 17554260]
| GWAS | |
|---|---|
| SNP | rs17388568 |
| PubMedID | [PMID 17554300]
|
| Condition | Type 1 diabetes |
| Gene | NR |
| Risk Allele | A |
| pValue | 3.00E-006 |
| OR | 1.26 |
| 95% CI | 1.11-1.42 |
[PMID 20184734] The 4q27 locus and familial prostate cancer risk
[PMID 20553587] Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
| GWAS snp | |
|---|---|
| PMID | [PMID 21297633]
|
| Trait | |
| Title | Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 |
| Risk Allele | A |
| P-val | 9E-7 |
| Odds Ratio | 1.1200 [1.07-1.17] |
| GWAS snp | |
|---|---|
| PMID | [PMID 21829393]
|
| Trait | |
| Title | Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. |
| Risk Allele | A |
| P-val | 0.000006 |
| Odds Ratio | 1.1000 [NR] |
[PMID 18369459] A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
[PMID 19140132] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
[PMID 19201773] Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.
[PMID 19359276] Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.
[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
[PMID 20722033] The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1.
[PMID 21875375] Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients.
| GWAS snp | |
|---|---|
| PMID | [PMID 23817569]
|
| Trait | Self-reported allergy |
| Title | A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. |
| Risk Allele | A |
| P-val | 4E-8 |
| Odds Ratio | .07 [0.047-0.099] unit increase |
