|A1/A1: Bad at avoidance of errors. 0.25x lower OCD; 0.56x lower Tardive Diskinesia; higher ADHD; 1.4x Alcohol Dependence; lower Postoperative Nausea; Increased obesity; less pleasure response; Bupropion ineffective for smoking cessation.; 2.4x risk for adenoma recurrence.|
|(C;T)||2.9||A1/A2: Bad at avoidance of errors. 0.5x lower OCD risk, 0.87x lower Tardive Diskinesia risk, higher ADHD risk. More Alcohol Dependence. Lower risk of Postoperative Nausea. Increased obesity. Bupropion is not effective for smoking cessation.|
|(T;T)||4||A1/A1: Bad at avoidance of errors. 0.25x lower OCD; 0.56x lower Tardive Diskinesia; higher ADHD; 1.4x Alcohol Dependence; lower Postoperative Nausea; Increased obesity; less pleasure response; Bupropion ineffective for smoking cessation.; 2.4x risk for adenoma recurrence.|
The DRD2 TaqIA A1/A1 version causes less dopamine receptors. Doesn't learn from mistakes well. Men have 0.25x reduced risk of Obsessive Compulsive Disorder but higher risk of ADHD. Women have lower Persistence. 0.56x reduced risk of Tardive Diskinesia when taking dopamine receptor antagonists. Slightly increased risk of alcoholism and smoking addiction. Slower recovery from traumatic brain injury. Lower risk of postoperative nausea within 6 hours of surgery. Bupropion (Wellbutrin, Budeprion, Prexaton, Elontril, Aplenzin, Zyban, Voxra) doesn't help to quit smoking[PMID 18058343]. Increased obesity due to decreased pleasure response to food. 2.4x increased risk for adenoma recurrence.
Extrapyramidal adverse effects are associated with increased drug occupancy of the dopamine 2 receptors DRD2. The A1 allele of the DRD2/ANKK1, rs1800497, is associated with decreased striatal DRD2 density. Results strongly suggested that A1+ variants of the DRD2/ANKK1 Taq1A allele do confer an associated risk for akathisia in patients who were treated with second-generation antipsychotics SGAs, and these variants may explain inconsistencies found across prior studies, when comparing FGAs and SGAs. [PMID 23118020]
Single marker analysis the TaqIA rs1800497 and TaqIB rs1079597 variants were associated with heroin dependence.
DRD2/ANKK1 Taq IA polymorphism is not associated with early infant temperament. There were no differences in the temperament style distribution between the T-carrier and non-T carrier groups. There were also no statistically significant differences between the two groups in the score of the nine temperament dimensions. [PMID 20199723]
[PMID 23118020] DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia.
[PMID 23840506] Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence.
[PMID 20199723] [DRD2/ANKK1 Taq IA polymorphism and early infant temperament].