| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
|
| (C;T)
|
3
|
2 - 3x higher prostate cancer risk if routinely exposed to the pesticide fonofos
|
| (T;T)
|
3
|
2 - 3x higher prostate cancer risk if routinely exposed to the pesticide fonofos
|
rs1983132 is a SNP in the NEIL3 gene on ch 4, which encodes a glycosylase that can initiate base excision repair.
A study of pesticide use and SNPs in ~800 prostate cancer cases revealed a significant association between men with either a rs1983132(C;T) or (T;T) genotype exposed to the pesticide fonofos and disease risk. The odds ratios and for low and high pesticide use versus no use were 1.65 (CI:0.91-3.01) and 3.25 (CI:1.78-5.92), respectively, whereas fonofos was not associated with prostate cancer risk among men with a rs1983132(C;C) genotype.[PMID 21810555
]
]
