rs2171492(T;T)

Higher prostate cancer risk

Is a	genotype
of	rs2171492
Gene	CPA4
Chromosome	7
Position	130,310,900
mentioned	by

Magnitude

2

Repute

Bad

Geno	Mag	Summary
(T;T)	2	Higher prostate cancer risk

Results: The nonsynonymous coding SNP (rs2171492, Cys303Gly) in CPA4 was associated with an increased risk of aggressive prostate cancer among younger patients (<66 years).

Specifically, men carrying the TT genotype had an approximately two-fold increased risk for being diagnosed with intermediate-to-high risk disease (Odds Ratio=1.83, p=0.04). In the overall population (all ages) none of the CPA4 SNPs demonstrated a statistically significant association with prostate cancer.

[PMID 19245716]