rs2229774
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common/normal |
| (C;T) | 3 | higher risk for anthracycline side-effects for childhood cancer patients |
| Make rs2229774(T;T) |
| Reference | GRCh38.p2 38.2/144 |
| Chromosome | 12 |
| Position | 53211761 |
| Gene | RARG |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2229774 |
| dbSNP (classic) | rs2229774 |
| ClinGen | rs2229774 |
| ebi | rs2229774 |
| HLI | rs2229774 |
| Exac | rs2229774 |
| Gnomad | rs2229774 |
| Varsome | rs2229774 |
| LitVar | rs2229774 |
| Map | rs2229774 |
| PheGenI | rs2229774 |
| Biobank | rs2229774 |
| 1000 genomes | rs2229774 |
| hgdp | rs2229774 |
| ensembl | rs2229774 |
| geneview | rs2229774 |
| scholar | rs2229774 |
| rs2229774 | |
| pharmgkb | rs2229774 |
| gwascentral | rs2229774 |
| openSNP | rs2229774 |
| 23andMe | rs2229774 |
| SNPshot | rs2229774 |
| SNPdbe | rs2229774 |
| MSV3d | rs2229774 |
| GWAS Ctlg | rs2229774 |
| Max Magnitude | 3 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs2229774, also known as p.Ser427Leu, in the RARG gene ups cardiotoxicity risk by roughly five times in children treated with the cancer drug anthracycline, based on a GWAS of a small number of anthracycline-treated childhood cancer patients (32 cases in the original discovery cohort and 22 in the replication population). The risk allele is the rare rs2229774(T) allele, in dbSNP orientation.10.1038/ng.3374
Categories:
- Is a snp
- In dbSNP
- SNPs on chromosome 12
- Has genotype
- Has population
- Uses doi
- On chip 23andMe v1
- On chip 23andMe v2
- On chip 23andMe v3
- On chip 23andMe v4
- On chip Affy GenomeWide 6
- On chip Ancestry v2
- On chip FTDNA2
- On chip FTDNA
- On chip HumanOmni1Quad
- On chip Illumina Human 1M
- On chip 23andMe v5
- On chip Ancestry v2c
- On chip Ancestry v2d
