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From SNPedia

Geno Mag Summary
(G;G) 2 Slightly lower risk of breast cancer
(G;T) 2 Slightly lower risk of breast cancer
(T;T) 0 most common genotype
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs2241766
1000 genomesrs2241766
GWAS Ctlgrs2241766
Max Magnitude2

rs2241766, also known as c.45T>G, represents a synonymous variant in the ADIPOQ gene on chromosome 3. Some studies report that the less common rs1501299(G) allele, is associated with decreased cancer risk compared with the more common (T) allele.

A study of 733 breast cancer cases for 10 SNPs concluded that the rs2241766(G;T) genotype, in combination with certain genotypes at rs1501299, was at reduced risk (odds ratio 0.61, CI: 0.46-0.80). After categorizing individuals by adiponectin signaling status, this study found that compared with low signalers (the most frequent), intermediate signalers had a 0.64x decrease in breast cancer risk (CI: 0.49–0.83), and high signalers had a 0.15x lower breast cancer risk (CI: 0.02–1.28, p(trend) = 0.001).[PMID 18451143OA-icon.png]

Adiponectin signaling status was assigned as follows (as oriented in dbSNP):

rs1501299(C,C) + rs2241766(T,T) = low signaler
rs1501299(A,C) + rs2241766(T,T) = low signaler
rs1501299(C,C) + rs2241766(G,T) = low signaler
rs1501299(A,A) + rs2241766(T,T) = intermediate signaler
rs1501299(A,C) + rs2241766(G,T) = intermediate signaler
rs1501299(C,C) + rs2241766(G,G) = intermediate signaler
rs1501299(A,C) + rs2241766(G,G) = high signaler
rs1501299(A,A) + rs2241766(G,G) = high signaler
rs1501299(A,A) + rs2241766(G,T) = high signaler

Based on these criteria, adiponectin signaling status is now determined by genosets Gs325 and Gs326 for Promethease users.

Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism.

In other words, you are a low adiponectin signaler, and thus have basically average breast cancer risk, if you have one of these combinations of alleles:

You are an intermediate adiponectin signaler (Gs325), and thus possibly at 0.64x reduced risk of breast cancer compared to low signallers, if you have one of these combinations of alleles:

You are a high adiponectin signaler (Gs326), and thus have the lowest (perhaps 0.15x) risk if you have one of these combinations of alleles:

[PMID 19573164] Association Study and Mutation Analysis of Adiponectin Shows Association of Variants in APM1 with Complex Obesity in Women


[PMID 19696691] Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis

[PMID 19631916] Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese

[PMID 20414354OA-icon.png] Analysis of adiponectin gene polymorphisms in chinese population with systemic lupus erythematosus

[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population

[PMID 20664545] Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

[PMID 21397927OA-icon.png] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk

[PMID 21516303OA-icon.png] Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes

[PMID 21619462] The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer

[PMID 21630088] Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults

[PMID 21637951] A common variant in the adiponectin gene and polycystic ovary syndrome risk

[PMID 21726267] A Meta-analysis on the Association of Adiponectin Gene Polymorphisms with Coronary Heart Disease in Chinese Han Population

[PMID 22459242] Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects

[PMID 22673923] An Association Study of SNP + 45 T > G of the AdipoQ Gene with Type 2 Diabetes in Yi and Han People in China

[PMID 22714914] Common polymorphisms (rs2241766 and rs1501299) in the ADIPOQ gene are not associated with hypertension susceptibility among the Chinese

[PMID 15616038] Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene.

[PMID 16990411] Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study.

[PMID 17357083OA-icon.png] Medical sequencing at the extremes of human body mass.

[PMID 17712123] Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women.

[PMID 18523726OA-icon.png] Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.

[PMID 18548168OA-icon.png] Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes.

[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18716158OA-icon.png] Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.

[PMID 18776141OA-icon.png] Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.

[PMID 18827209OA-icon.png] Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.

[PMID 19035456OA-icon.png] Adipokine genes and prostate cancer risk.

[PMID 19037660OA-icon.png] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.

[PMID 19238139OA-icon.png] ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.

[PMID 19661719] Interaction of ADIPOQ genetic polymorphism with blood pressure and plasma cholesterol level on the risk of coronary artery disease.

[PMID 19755407OA-icon.png] Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women.

[PMID 19912668OA-icon.png] Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study.

[PMID 20201642] Associations of polymorphisms in adiponectin and leptin genes with men's longevity.

[PMID 20230294] Analysis of adiponectin gene polymorphisms in dilated cardiomyopathy in a Han Chinese population.

[PMID 20848215] Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population.

[PMID 21054480] Genetic effects of adiponectin on blood lipids and blood pressure.

[PMID 21219602OA-icon.png] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.

[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.

[PMID 21638131] Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.

[PMID 22070425] Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.

[PMID 22386722] Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.

[PMID 22391941] Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.

[PMID 22583123OA-icon.png] Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist-Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India.

[PMID 23041095] Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction

[PMID 23118546OA-icon.png] Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population

[PMID 23143890] Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis

[PMID 23151860] +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia

[PMID 23200411] ADIPOQ gene polymorphisms and cancer risk: A meta-analysis

[PMID 23370338] Adiponectin gene polymorphisms may not be associated with idiopathic premature ovarian failure

[PMID 23653335] AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study

[PMID 23658423] Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals

[PMID 23740135] The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk

[PMID 23803590] Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia

[PMID 23260797] Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes

[PMID 23805506] [Association of adiponectin gene polymorphrism with metabolic syndrome in older Han adults from major cities in China]

[PMID 23819115OA-icon.png] Association of Atherosclerotic Peripheral Arterial Disease with Adiponectin Genes SNP+45 and SNP+276: A Case-Control Study

[PMID 23826253OA-icon.png] Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study

[PMID 23972466] Association Between the Adiponectin +45T>G Genotype and Risk of Cardiovascular Disease: A Meta-analysis

[PMID 24293390] An updated meta-analysis of the association between ADIPOQ rs2241766 polymorphism and colorectal cancer

[PMID 24559720] Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome

[PMID 23065236] The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies.

[PMID 23144319] Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.

[PMID 23144325OA-icon.png] P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.

[PMID 23552441] Association of adiponectin gene polymorphism with birth weight in Korean neonates.

[PMID 24894086] Adiponectin gene (ADIPOQ) polymorphisms correlate with the progression of nephropathy in Taiwanese male patients with type 2 diabetes

[PMID 25074391] Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents

[PMID 25135112] Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses

[PMID 25223469] Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis

[PMID 26329379OA-icon.png] Adiponectin Gene Polymorphisms are Associated with Increased Risk of Colorectal Cancer

[PMID 26546898] Plasma Adiponectin Concentrations and Adiponectin Gene Polymorphisms Are Associated with Bronchial Asthma in the Chinese Li Population

[PMID 26884098OA-icon.png] Single Nucleotide Polymorphism (SNP) in the Adiponectin Gene and Cardiovascular Disease.

[PMID 26887769] [Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].

[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.

[PMID 28737466] Association of AdipoQ single-nucleotide polymorphisms and smoking interaction with the risk of coronary heart disease in Chinese Han population.

[PMID 29428584] The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.

[PMID 29627525] Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population.

[PMID 29629043OA-icon.png] Lower Levels of Serum Adiponectin and the T Allele of rs1501299 of the ADIPOQ Gene Are Protective against Polycystic Ovarian Syndrome in Jordan.

[PMID 29633340OA-icon.png] Contribution of adiponectin polymorphisms to the risk of coronary artery disease in a North-African Tunisian population.

[PMID 30041843] Genetic susceptibility to pre diabetes mellitus and related association with obesity and physical fitness components in Mexican-Mestizos.

[PMID 30360393OA-icon.png] Association of Adiponectin and rs1501299 of the ADIPOQ Gene with Prediabetes in Jordan.

[PMID 30678425OA-icon.png] Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma

[PMID 30883598OA-icon.png] ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population.

[PMID 31038568] Adipokine gene variability and plasma levels in patients with chronic periodontitis -a case-control study.

[PMID 31565221OA-icon.png] Levels of nitric oxide metabolites, adiponectin and endothelin are associated with SNPs of the adiponectin and endothelin genes.

[PMID 31807045OA-icon.png] Polymorphism Of The APM1 Gene In Subjects With Central Obesity Related To Lower High-Density Lipoprotein Cholesterol.

[PMID 32685557OA-icon.png] ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease.

[PMID 32977760OA-icon.png] ADIPOQ single nucleotide polymorphisms and breast cancer in northeastern Mexican women.