rs2298383
Orientation | plus |
Stabilized | plus |
Geno | Mag | Summary |
---|---|---|
(C;C) | 2 | increased anxiety in response to caffeine |
(C;T) | 0 | |
(T;T) | 0 |
Reference | GRCh38 38.1/141 |
Chromosome | 22 |
Position | 24429543 |
Gene | ADORA2A, ADORA2A-AS1, SPECC1L-ADORA2A |
is a | snp |
is | mentioned by |
dbSNP | rs2298383 |
dbSNP (classic) | rs2298383 |
ClinGen | rs2298383 |
ebi | rs2298383 |
HLI | rs2298383 |
Exac | rs2298383 |
Gnomad | rs2298383 |
Varsome | rs2298383 |
LitVar | rs2298383 |
Map | rs2298383 |
PheGenI | rs2298383 |
Biobank | rs2298383 |
1000 genomes | rs2298383 |
hgdp | rs2298383 |
ensembl | rs2298383 |
geneview | rs2298383 |
scholar | rs2298383 |
rs2298383 | |
pharmgkb | rs2298383 |
gwascentral | rs2298383 |
openSNP | rs2298383 |
23andMe | rs2298383 |
SNPshot | rs2298383 |
SNPdbe | rs2298383 |
MSV3d | rs2298383 |
GWAS Ctlg | rs2298383 |
GMAF | 0.4816 |
Max Magnitude | 2 |
? | (C;C) (C;T) (T;T) | 28 |
---|---|---|
|
Variation at this SNP, rs2298383, appears to influence how an individual responds to moderate levels (150mg) of caffeine.[PMID 18305461]
[PMID 20334879] Adenosine A(2A) receptor gene: Evidence for association of risk variants with panic disorder and anxious personality
[PMID 22336631] Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.
[PMID 23535492] ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus
[PMID 26589317] The RS685012 Polymorphism of ACCN2, the Human Ortholog of Murine Acid-Sensing Ion Channel (ASIC1) Gene, is Highly Represented in Patients with Panic Disorder
ClinVar | |
---|---|
Risk | rs2298383(A;A) Rs2298383(T;T) |
Alt | rs2298383(A;A) Rs2298383(T;T) |
Reference | Rs2298383(C;C) |
Significance | Drug-response |
Disease | caffeine response - Toxicity/ADR |
Variation | info |
Gene | SPECC1L-ADORA2A ADORA2A-AS1 ADORA2A |
CLNDBN | caffeine response - Toxicity/ADR |
Reversed | 0 |
HGVS | NC_000022.10:g.24825511C>A |
CLNSRC | PharmGKB Clinical Annotation PharmGKB |
CLNACC | RCV000417154.1, |
[PMID 30511252] Impact of genetic variations in ADORA2A gene on depression and symptoms: a cross-sectional population-based study.
[PMID 31817803] The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep.
[PMID 32182774] The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity.
[PMID 32615857] The influence of coffee intake and genetics on adenosine pathway in rheumatoid arthritis.