|(G;G)||2||2x risk for Crohn's; 1.6x for T1D|
|(G;T)||1.3||1.3x risk for Crohn's; 1.3x for T1D|
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.3 (CI 1.14-1.48), and for homozygotes, 2.01 (CI 1.46-2.76). [PMID 17554300]
rs2542151 has been reported in the same study to be associated with type-1 diabetes. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.30 (CI 1.15-1.47), and for homozygotes, 1.62 (CI 1.17-2.24). [PMID 17554300]
In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.30 (CI 1.22â€“1.40). [PMID 17554260]
|Condition||Type 1 diabetes|
|Trait||Type 1 diabetes|
|Title||Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci|
|Odds Ratio||NR NR|
|Title||Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease|
|Odds Ratio||1.35 [NR]|
|Title||Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility|
|Odds Ratio||1.15 [1.00-1.32]|
[PMID 19565500] Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis
[PMID 19953089] Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
[PMID 21246196] A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes
|Title||Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.|
|Odds Ratio||1.3000 [NR]|
[PMID 22377701] PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.
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