rs258322

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(T;T)	3	2x increased risk of Melanoma

Make rs258322(C;C)

Make rs258322(C;T)

Reference

GRCh38 38.1/141

Chromosome

16

Position

89689495

Gene

CDK10

is a	snp
is	mentioned by
dbSNP	rs258322
dbSNP (classic)	rs258322
ClinGen	rs258322
ebi	rs258322
HLI	rs258322
Exac	rs258322
Gnomad	rs258322
Varsome	rs258322
LitVar	rs258322
Map	rs258322
PheGenI	rs258322
Biobank	rs258322
1000 genomes	rs258322
hgdp	rs258322
ensembl	rs258322
geneview	rs258322
scholar	rs258322
google	rs258322
pharmgkb	rs258322
gwascentral	rs258322
openSNP	rs258322
23andMe	rs258322
SNPshot	rs258322
SNPdbe	rs258322
MSV3d	rs258322
GWAS Ctlg	rs258322

GMAF

0.2677

Max Magnitude

3

?	(C;C) (C;T) (T;T)	28

GWAS snp
PMID	[PMID 18483556]
Trait	Black vs. red hair color
Title	A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
Risk Allele	T
P-val	1.9999999999999999E-23
Odds Ratio	0.36 [0.28-0.44] increase in hair color score

GWAS snp
PMID	[PMID 19578364]
Trait	Melanoma
Title	Genome-wide association study identifies three loci associated with melanoma risk
Risk Allele	A
P-val	3E-27
Odds Ratio	1.67 [1.52-1.83]

OMIM	606933
Desc	TYROSINASE; TYR
Variant
Related	also

OMIM	155601
Desc
Variant
Related	also

OMIM	601800
Desc
Variant
Related	also

OMIM	613099
Desc
Variant
Related	also

GWAS snp
PMID	[PMID 21983787]
Trait
Title	Genome-wide association study identifies three new melanoma susceptibility loci.
Risk Allele	A
P-val	3E-27
Odds Ratio	1.7000 None

This SNP occurs within CDK10, (cyclin-dependent kinase 10). The T variant has been associated with increased risk of Melanoma (OR=1.67, 95%CI 1.52-1.83) [PMID 19578364], (OR=2.26, 95%CI 1.32–3.88) [PMID 23393597].

References

[PMID 19578364] Genome-wide association study identifies three loci associated with melanoma risk.

23andMe blog rs258322 A (T in dbSNP): OR 1.67 for Melanoma

[PMID 23393597] Replication and Predictive Value of SNPs Associated with Melanoma and Pigmentation Traits in a Southern European Case-Control Study

[PMID 19340012] Genome-wide association study of tanning phenotype in a population of European ancestry.

[PMID 19686382] Genome-wide associations studies for melanoma and nevi.

GWAS snp
PMID	[PMID 24980573]
Trait	Melanoma
Title	Identification of a melanoma susceptibility locus and somatic mutation in TET2.
Risk Allele	A
P-val	2E-9
Odds Ratio	1.50 [1.31-1.71]