|(C;G)||1.8||0.73x decreased risk for colorectal cancer|
|(G;G)||2||0.73x decreased risk for colorectal cancer|
Two case-control studies including colorectal cancer patients and controls were conducted; the first case involving 441 patients and 658 controls, all of Ashkenazi Jewish ancestry, and the second including 199 patients and 199 matched (sex, age and ethnicity) controls.
rs266729(G) showed decreased colorectal cancer risk in both studies; in the first, with an odds ratio of 0.72 (CI:0.55-0.95) and in the second, with an odds ratio of 0.52 (CI: 0.34-0.78). Combining the two studies led to an overall decreased colorectal cancer odds ratio of 0.73 (CI: 0.53-0.99) for this allele.
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[PMID 19324915] Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus.
[PMID 19360113] The Role of the PGC1alpha Gly482Ser Polymorphism in Weight Gain due to Intensive Diabetes Therapy.
[PMID 19593725] Association of maternally inherited GNAS alleles with African-American male birth weight.
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[PMID 20114006] SOX2 has gender-specific genetic effects on diabetic nephropathy in samples from patients with type 1 diabetes mellitus in the GoKinD study.
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[PMID 20554072] Gestational diabetes mellitus screening based on the gene chip technique.
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[PMID 21219602] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.
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[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.
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[PMID 23041553] Genetic association of adipnectin with type 2 diabetes in Jordanian Arab population
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[PMID 25038177] Genetic variations of the ADIPOQgene and risk of prostate cancer in Chinese Han men
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[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.
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