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Mag
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Summary
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| (A;A)
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0
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common in complete genomics
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rs35667974, also known as Ile923Val, is a SNP in the interferon induced with helicase C domain 1 IFIH1 gene.
A recent study apparently found this SNP had the strongest association with type-1 diabetes; however, in a study of 3,000 European multiple sclerosis patients, no association was seen.[PMID 20116863
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[PMID 20668468] Carriers of rare missense variants in IFIH1 are protected from psoriasis
[PMID 20736039] Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-? production in peripheral blood mononuclear cells of type 1 diabetes patients
[PMID 22110759] Polymorphisms in the Innate Immune IFIH1 Gene, Frequency of Enterovirus in Monthly Fecal Samples during Infancy, and Islet Autoimmunity
[PMID 19961590] The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.
[PMID 23144876] Enterovirus RNA in Peripheral Blood May Be Associated with the Variants of rs1990760, a Common Type 1 Diabetes Associated Polymorphism in IFIH1
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