| Geno
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Mag
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Summary
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| (C;C)
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1.1
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0.6x decreased risk for cervical cancer, but 1.4x increased risk for HNSCC and 1.8x increased risk for breast cancer (reported in 2008)
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| (C;T)
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1.1
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0.5x decreased risk for cervical cancer, HNSCC, and breast cancer (reported in 2008)
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| (T;T)
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1.1
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1.5x - 2x increased risk for cervical cancer, HNSCC, and breast cancer (reported in 2008)
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rs3738579 represents a SNP in the 5' UTR region upstream of the RNASEL gene.
A study of patients diagnosed with carcinoma of the uterine cervix, head and neck squamous cell carcinomas (HNSCC), and breast cancer found 1.5x-2x increased risk for all three cancer types for the rs3738579(T;T) genotype, while finding decreased risk (0.5x) for rs3738579(C;T) heterozygotes. rs3738579(C;C) homozygotes had 0.6x less risk for cervical cancer but increased risk for HNSCC (1.4x) and breast cancer (1.8x).[PMID 18575592
]
Although statistics were not reported per genotype, a combination of data from all three cancer forms over all genotypes provided strong statistical evidence for rs3738579 as a cancer marker, with a p-value of 4.43x10(-5).[PMID 18575592]
Note that the research cited above was published over a decade ago, and there has been no follow-up or replication to our knowledge. It would be best to consider the research preliminary and perhaps of little to no clinical significance (until it is confirmed or replicated in a larger sample).
]
