rs3766379
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | 1.37x increased risk for rheumatoid arthritis | |
| (T;T) | 1.9x increased risk for rheumatoid arthritis |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 160837925 |
| Gene | CD244 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3766379 |
| dbSNP (classic) | rs3766379 |
| ClinGen | rs3766379 |
| ebi | rs3766379 |
| HLI | rs3766379 |
| Exac | rs3766379 |
| Gnomad | rs3766379 |
| Varsome | rs3766379 |
| LitVar | rs3766379 |
| Map | rs3766379 |
| PheGenI | rs3766379 |
| Biobank | rs3766379 |
| 1000 genomes | rs3766379 |
| hgdp | rs3766379 |
| ensembl | rs3766379 |
| geneview | rs3766379 |
| scholar | rs3766379 |
| rs3766379 | |
| pharmgkb | rs3766379 |
| gwascentral | rs3766379 |
| openSNP | rs3766379 |
| 23andMe | rs3766379 |
| SNPshot | rs3766379 |
| SNPdbe | rs3766379 |
| MSV3d | rs3766379 |
| GWAS Ctlg | rs3766379 |
| GMAF | 0.4656 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
Two SNPs on ch 1q in the CD244 gene, rs3766379 and rs6682654, were found to be associated with risk for rheumatoid arthritis in two independent Japanese cohorts (p = 3.23 x 10e-8) and p = 7.45 x 10e-8). The odds ratio reported for the more common rs3766379(T) allele was 1.37 (CI: 1.18-1.59, p = 0.0001).[PMID 18794858]
[PMID 20437071] Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus.
| ClinVar | |
|---|---|
| Risk | Rs3766379(C;C) |
| Alt | Rs3766379(C;C) |
| Reference | Rs3766379(T;T) |
| Significance | Other |
| Disease | Rheumatoid arthritis |
| Variation | info |
| Gene | CD244 |
| CLNDBN | Rheumatoid arthritis |
| Reversed | 0 |
| HGVS | NC_000001.10:g.160807715T>C |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000005173.2, |
