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rs5275

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0.68x decreased risk for bladder cancer
(C;T) 0.68x decreased risk for bladder cancer
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome1
Position186673926
GenePTGS2
is asnp
is mentioned by
dbSNPrs5275
dbSNP (classic)rs5275
ClinGenrs5275
ebirs5275
HLIrs5275
Exacrs5275
Gnomadrs5275
Varsomers5275
LitVarrs5275
Maprs5275
PheGenIrs5275
Biobankrs5275
1000 genomesrs5275
hgdprs5275
ensemblrs5275
geneviewrs5275
scholarrs5275
googlers5275
pharmgkbrs5275
gwascentralrs5275
openSNPrs5275
23andMers5275
SNPshotrs5275
SNPdbers5275
MSV3drs5275
GWAS Ctlgrs5275
GMAF0.3586
Max Magnitude0
? (C;C) (C;T) (T;T) 28


rs5275, also known as exon1-+837T>C, is a SNP in the PTGS2 gene.

A study of 635 Caucasian bladder cancer patients found a reduced risk associated with the minor (C) allele of rs5275, (odds ratio 0.68, CI: 0.54-0.87, p=0.002, remaining significant after multiple comparison adjustment).[PMID 18381966]

[PMID 19219602] (T;T) genotype of PTGS2 8473T>C (rs5275) was significantly correlated with a better survival when compared to the combined T/C and C/C genotype (Hazard ratio [HR] = 0.47; P value = 0.046 and HR = 0.16; P = 0.013, respectively) in colorectal cancer


[PMID 19455278] Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population


[PMID 19748095] Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome

[PMID 19820421] The Effect of Genetic Polymorphisms of Cyclooxygenase 2 on Acute Pancreatitis in Turkey


[PMID 20033767] Current evidence on the relationship between polymorphisms in the COX-2 gene and breast cancer risk: a meta-analysis


[PMID 19773451OA-icon.png] Role of inflammation gene polymorphisms on pain severity in lung cancer patients


[PMID 20472470] Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 Polymorphisms on 90-Day Ischemic Stroke Functional Outcome: A Novel Finding

[PMID 20559705OA-icon.png] Pooled analysis of the association of PTGS2 rs5275 polymorphism and NSAID use with invasive ovarian carcinoma risk

[PMID 20686383] Cyclooxygenase-2 gene polymorphisms and risk of cervical cancer in a North Indian population


[PMID 21816595] A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population


[PMID 21705955] Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility

[PMID 16205694OA-icon.png] Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma.

[PMID 17066444] Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism.

[PMID 17171651] Cyclooxygenase-2 polymorphisms in Parkinson's disease.

[PMID 17181859OA-icon.png] Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk.

[PMID 17214885OA-icon.png] A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study.

[PMID 17356794] Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract.

[PMID 17404026] Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population.

[PMID 17999989] Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies.

[PMID 18085997] Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

[PMID 18454203OA-icon.png] Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression.

[PMID 18471798OA-icon.png] Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.

[PMID 18768181OA-icon.png] Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

[PMID 18989535] Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease.

[PMID 18992148OA-icon.png] Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

[PMID 19197984OA-icon.png] Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions.

[PMID 19318492OA-icon.png] Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.

[PMID 19437564OA-icon.png] No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk.

[PMID 19505919OA-icon.png] Toll-like receptor signaling pathway variants and prostate cancer mortality.

[PMID 19890662] TNF superfamily gene polymorphism as prognostic factor in early breast cancer.

[PMID 19930591OA-icon.png] Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.

[PMID 20444268OA-icon.png] Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.

[PMID 20803508] Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study.

[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 21042835] Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma.

[PMID 21283657OA-icon.png] Gallbladder cancer predisposition: a multigenic approach to DNA-repair, apoptotic and inflammatory pathway genes.

[PMID 21304218] Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.

[PMID 21371074OA-icon.png] The risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors does not vary with polymorphisms in two regions of the cyclo-oxygenase-2 gene.

[PMID 22023987] Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort.

[PMID 22037828] Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features.

[PMID 22385256] A genetic variant in 3'-untranslated region of cyclooxygenases-2 gene is associated with risk of gastric cancer in a chinese population.

[PMID 22487732] Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression.


[PMID 23444045] Association between a functional variant at PTGS2 gene 3'UTR and its mRNA expression in lymphoblastoid cell lines


[PMID 23531863OA-icon.png] An association between the PTGS2 rs5275 polymorphism and colorectal cancer risk in families with inherited non-syndromic predisposition


[PMID 24194923OA-icon.png] Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study


[PMID 22464751OA-icon.png] SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors.


[PMID 23029430OA-icon.png] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.


[PMID 25166592OA-icon.png] Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis


[PMID 25214704OA-icon.png] Association of the Three Common SNPs of Cyclooxygenase-2 Gene (rs20417, rs689466, and rs5275) with the Susceptibility of Breast Cancer: An Updated Meta-Analysis Involving 34,590 Subjects


[PMID 25304949] Role of Genetic Polymorphisms in NFKB-Mediated Inflammatory Pathways in Response to Primary Chemoradiation Therapy for Rectal Cancer


[PMID 25900875] Polymorphisms in cyclooxygenase-2 gene in endometrial cancer patients


[PMID 26081267OA-icon.png] Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients


[PMID 28583914OA-icon.png] Association between COL11A1 (rs1337185) and ADAMTS5 (rs162509) gene polymorphisms and lumbar spine pathologies in Chinese Han population: an observational study.


[PMID 30087034] The association between COX-2 gene rs5275 polymorphism and Nasopharyngeal carcinoma risk.


[PMID 32140313OA-icon.png] Novel association between TGFA, TGFB1, IRF1, PTGS2 and IKBKB single-nucleotide polymorphisms and occurrence, severity and treatment response of major depressive disorder.


[PMID 32655394OA-icon.png] Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study.


[PMID 33275396] Association between plasma prostaglandin E2 level and colorectal cancer.