|(A;A)||2||2.40x increased risk of cleft lip|
|(A;G)||1.5||1.68x increased risk of cleft lip|
|(G;G)||1||Normal risk of cleft lip|
|Trait||Nonsyndromic cleft lip with or without cleft palate|
|Title||Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24|
|Odds Ratio||NR NR|
[PMID 19521098] Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results.
[PMID 19780991] Lack of association between IRF6 polymorphisms (rs2235371 and rs642961) and non-syndromic cleft lip and/or palate in a Brazilian population.
[PMID 19881024] Current concepts in genetics of nonsyndromic clefts.
[PMID 20032603] Studies of palatine rugae and interferon regulatory factor 6 variations in a group of families with sporadic hypodontia.
[PMID 20121942] IRF6 gene variants in Central European patients with non-syndromic cleft lip with or without cleft palate.
[PMID 20196142] Family-based study shows heterogeneity of a susceptibility locus on chromosome 8q24 for nonsyndromic cleft lip and palate.
[PMID 20544801] Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population.
[PMID 20799332] IRF6 polymorphisms are associated with nonsyndromic orofacial clefts in a Chinese Han population.
[PMID 21683068] Single-nucleotide polymorphisms (SNPs) of the IRF6 and TFAP2A in non-syndromic cleft lip with or without cleft palate (NSCLP) in a northern Chinese population.
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[PMID 22113860] MCS9.7 enhancer activity is highly, but not completely, associated with expression of Irf6 and p63.
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[PMID 30419764] Association Studies Between Regulatory Regions of IRF6/ TP63 Genes and Nonsyndromic Oral Clefts.
[PMID 30579133] Polymorphisms associated with oral clefts as potential susceptibility markers for oral and breast cancer.