rs6822844
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common on affy axiom data |
| Make rs6822844(G;T) |
| Make rs6822844(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 122588266 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6822844 |
| dbSNP (classic) | rs6822844 |
| ClinGen | rs6822844 |
| ebi | rs6822844 |
| HLI | rs6822844 |
| Exac | rs6822844 |
| Gnomad | rs6822844 |
| Varsome | rs6822844 |
| LitVar | rs6822844 |
| Map | rs6822844 |
| PheGenI | rs6822844 |
| Biobank | rs6822844 |
| 1000 genomes | rs6822844 |
| hgdp | rs6822844 |
| ensembl | rs6822844 |
| geneview | rs6822844 |
| scholar | rs6822844 |
| rs6822844 | |
| pharmgkb | rs6822844 |
| gwascentral | rs6822844 |
| openSNP | rs6822844 |
| 23andMe | rs6822844 |
| SNPshot | rs6822844 |
| SNPdbe | rs6822844 |
| MSV3d | rs6822844 |
| GWAS Ctlg | rs6822844 |
| GMAF | 0.06749 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 17999365
] association with rheumatoid arthritis and type-1 diabetes point to a general risk locus for autoimmune diseases.
Also, of SNPs outside the HLA region, this SNP and one other (rs13119723) in the region of the IL21 gene showed the strongest association with celiac disease in a study of ~800 Caucasian patients and a meta-analysis of two further populations.[PMID 17558408]
| GWAS | |
|---|---|
| SNP | rs6822844 |
| PubMedID | [PMID 17558408]
|
| Condition | Celiac disease |
| Gene | KIA1109,TENR,IL2,IL21 |
| Risk Allele | G |
| pValue | 1.00E-014 |
| OR | 1.59 |
| 95% CI | 1.41-1.75 |
[PMID 19302705] Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study.
| GWAS snp | |
|---|---|
| PMID | [PMID 18311140]
|
| Trait | Celiac disease |
| Title | Newly identified genetic risk variants for celiac disease related to the immune response |
| Risk Allele | C |
| P-val | 2.9999999999999998E-13 |
| Odds Ratio | 1.44 [1.30-1.58] |
[PMID 19455118] Novel Genetic Risk Markers for Ulcerative Colitis in the IL2/IL21 Region Are in Epistasis With IL23R and Suggest a Common Genetic Background for Ulcerative Colitis and Celiac Disease
[PMID 19471255] Novel Association of the Interleukin 2-Interleukin 21 Region With Inflammatory Bowel Disease
[PMID 19201773] Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis
[PMID 19404967] Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis
[PMID 20184734] The 4q27 locus and familial prostate cancer risk
[PMID 20553587] Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: Confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance
[PMID 22130325] IL-23R rs11209026 polymorphism modulates IL-17A expression in patients with rheumatoid arthritis
[PMID 22087237] Improving the estimation of celiac disease sibling risk by non-HLA genes
[PMID 21269573] Role of the rs6822844 gene polymorphism at the IL2-IL21 region in biopsy-proven giant cell arteritis.
[PMID 18369459] A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
[PMID 18418394] Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families.
[PMID 18713140] Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.
[PMID 18794853] Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 19073967] Shared and distinct genetic variants in type 1 diabetes and celiac disease.
[PMID 19176549] Genome-wide association analysis by lasso penalized logistic regression.
[PMID 19180477] Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.
[PMID 19248117] Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis.
[PMID 19359276] Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.
[PMID 19468064] Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
[PMID 19523143] Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population.
[PMID 19546505] IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H).
[PMID 20072139] Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis.
[PMID 20112382] Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus.
[PMID 20179739] Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.
[PMID 20444755] Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
[PMID 20445516] Consolidation of evidence for association of the KIAA1109-TENR-IL2-IL21 rs6822844 variant with Crohn's disease.
[PMID 21304239] Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis.
[PMID 21375519] A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21.
[PMID 21383967] Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
[PMID 21875375] Study of polymorphisms in 4q27, 10p15, and 22q13 regions in autoantibodies stratified type 1 diabetes patients.
[PMID 23172754] Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility
[PMID 22328738] Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
[PMID 23645042] IL2/IL21 region polymorphism influences response to rituximab in systemic lupus erythematosus patients.
[PMID 25037274] Autoimmune diseases association study with the KIAA1109-IL2-IL21 region in a Tunisian population
[PMID 26535636] Association between IL2/IL21 and SH2B3 polymorphisms and risk of celiac disease: a meta-analysis
[PMID 31519598] Genetic Variants of the IL2 Gene Related to Risk and Survival in Patients With Colorectal Cancer.
