rs6869366
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | >2x increased risk for bladder cancer | |
| (G;T) | 2x increased risk for bladder cancer | |
| (T;T) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 83075927 |
| Gene | TMEM167A, XRCC4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6869366 |
| dbSNP (classic) | rs6869366 |
| ClinGen | rs6869366 |
| ebi | rs6869366 |
| HLI | rs6869366 |
| Exac | rs6869366 |
| Gnomad | rs6869366 |
| Varsome | rs6869366 |
| LitVar | rs6869366 |
| Map | rs6869366 |
| PheGenI | rs6869366 |
| Biobank | rs6869366 |
| 1000 genomes | rs6869366 |
| hgdp | rs6869366 |
| ensembl | rs6869366 |
| geneview | rs6869366 |
| scholar | rs6869366 |
| rs6869366 | |
| pharmgkb | rs6869366 |
| gwascentral | rs6869366 |
| openSNP | rs6869366 |
| 23andMe | rs6869366 |
| SNPshot | rs6869366 |
| SNPdbe | rs6869366 |
| MSV3d | rs6869366 |
| GWAS Ctlg | rs6869366 |
| GMAF | 0.09504 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs6869366, also known as G-1394T, is a SNP in the DNA repair XRCC4 gene.
A study of 158 Taiwanese patients found an association between carriers of a rs6869366(G) allele and increased risk for bladder cancer. The odds ratio was 2x for heterozygotes; no (T;T) homozygotes were seen in this study.[PMID 19443403]
Risk was further studied based on smoking history. Smokers who were also rs6869366(T) carriers were at even higher risk (crude OR=3.29, CI: 1.21-8.90, adjusted OR=3.35, CI=1.41-8.49), implying a gene-smoking interaction.[PMID 19443403]
[PMID 19729825] Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan
[PMID 20332465] Significant association of XRCC4 single nucleotide polymorphisms with childhood leukemia in Taiwan
[PMID 20683005] Colorectal Cancer and Genetic Polymorphism of DNA Double-strand Break Repair Gene XRCC4 in Taiwan
[PMID 21617942] Gene variants of XRCC4 and XRCC3 and their association with risk for urothelial bladder cancer
[PMID 21717429
] Genetic variants of the nonhomologous end joining gene LIG4 and severe radiation pneumonitis in nonsmall cell lung cancer patients treated with definitive radiotherapy
[PMID 17987338] A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan.
[PMID 18164646] A novel single nucleotide polymorphism in XRCC4 gene is associated with oral cancer susceptibility in Taiwanese patients.
[PMID 18630527] Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan.
[PMID 21506695] Do polymorphisms in XRCC4 influence prostate cancer susceptibility in North Indian population?
[PMID 23924833] Association of XRCC3 and XRCC4 gene polymorphisms, family history of cancer and tobacco smoking with non-small-cell lung cancer in a Chinese population: a case-control study
