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From SNPedia

substance dependence (SD) SNP
Geno Mag Summary
(C;C) 2.5 Associated with Alcohol Dependence; associated with nicotine dependence (female)
(T;T) 0 common/normal
Make rs806368(C;T)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs806368
1000 genomesrs806368
GWAS Ctlgrs806368
Max Magnitude2.5
? (C;C) (C;T) (T;T) 28

[PMID 17509535] risk of the development of substance dependence significantly increased with the number of "G" alleles at rs6454674 and SNP8 (rs806368);T/T genotypes had significant interaction effects (p = .0003 for comorbid drug dependence (DD) and alcohol dependence (AD), .0002 for DD, and .007 for AD). SNP3 and SNP8 together exerted stronger genetic effects on SD (substance dependence) than either did individually. The peak delta values among all the markers were seen for SNP3 and SNP8 (rs806368)

[PMID 19052543OA-icon.png] Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

[PMID 18213623OA-icon.png] rs806368(C) together with rs1049353(A) or rs1049353(G) make up a haplotype associated with PTSD, with the C-A haplotype somewhat associated (p=0.04) with higher risk of PTSD and the C-G haplotype associated (p=0.01) with a lower risk of PTSD.

[PMID 22085192] Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence.

Alcoholic patients with TGT haplotype (corresponding to rs6454674-rs1049353-rs806368 polymorphisms in this order) were less prone to have AD (p = 0.017). TGC haplotype were more likely to develop AD.

[PMID 18179391] Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians.

Impulsivity was significantly associated with the 6-repeat allele of the triplet repeat polymorphism (AATn/A6; p < .0001), as well as four SNPs in or near the CNR1 receptor gene: rs1535255 (p = .001), rs2023239 (p = .004), rs1049353 (p < .001) and rs806368 (p < .0006). These studies provide data to suggest that the CNR1 receptor gene may be significantly associated with impulsivity in SWC Indians.

[PMID 18606954OA-icon.png] Cannabinoid receptor 1 gene association with nicotine dependence.

the associations were female specific. Haplotype 1-1-2 of markers rs2023239-rs12720071-rs806368(C) was associated with nicotine dependence and FTND score in the 2 samples (P < .001 and P = .009, respectively).

[PMID 18776593OA-icon.png] Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population.

[PMID 19016476OA-icon.png] Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.

[PMID 19018721OA-icon.png] Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.

[PMID 19335651OA-icon.png] Candidate genes for cannabis use disorders: findings, challenges and directions.

[PMID 19886064] The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects.

[PMID 20415562] Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity.

[PMID 20838400] Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?

[PMID 21129839] A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.

[PMID 21695734] Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain.

[PMID 21790903OA-icon.png] Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.

[PMID 24407958] Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures

[PMID 23407780] Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.

[PMID 25093427] Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome

[PMID 25136364OA-icon.png] Cannabinoid receptor 1 gene polymorphisms and nonalcoholic Fatty liver disease in women with polycystic ovary syndrome and in healthy controls

[PMID 26756393OA-icon.png] Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families.

[PMID 28349993] Cannabinoid Receptor Type 1 and mu-Opioid Receptor Polymorphisms Are Associated With Cyclic Vomiting Syndrome.

[PMID 32433545OA-icon.png] Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia.