| 1.7x increased risk of melanoma; increased risk of squamous cell carcinoma |
| Geno
|
Mag
|
Summary
|
| (A;A)
|
4
|
3x increased risk of melanoma
|
| (A;G)
|
3
|
1.7x increased risk of melanoma; increased risk of squamous cell carcinoma
|
| (G;G)
|
0
|
normal
|
You carry one allele associated with an increased risk for melanoma and squamous cell carcinoma. Watch for unusual or expanding skin growths or moles, always use SPF 30, and avoid the direct sun between 10am and 4pm.
[PMID 19995372
]
In a nested case-control study based on the Nurses Health Study, the correlation between rs910873 and skin cancer was examined in a Caucasian population. This study included 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCS) cases, and 870 age-matched controls. rs910873 was found to be significantly associated with increased risks of melanoma and SCC (but not BSC) in both additive (additive OR for melanoma, 1.67; 95% CI, 1.19–2.34; additive OR for SCC, 1.51; 95% CI, 1.09-2.10) and dominant models (G;A or A;A; dominant OR for melanoma, 1.81; 95% CI, 1.23-2.67; dominant OR for SCC, 1.70; 95% CI, 1.19-2.43). P for trends = 0.01 and 0.003 for melanoma and SCC, respectively.
]
In a nested case-control study based on the Nurses Health Study, the correlation between rs910873 and skin cancer was examined in a Caucasian population. This study included 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCS) cases, and 870 age-matched controls. rs910873 was found to be significantly associated with increased risks of melanoma and SCC (but not BSC) in both additive (additive OR for melanoma, 1.67; 95% CI, 1.19–2.34; additive OR for SCC, 1.51; 95% CI, 1.09-2.10) and dominant models (G;A or A;A; dominant OR for melanoma, 1.81; 95% CI, 1.23-2.67; dominant OR for SCC, 1.70; 95% CI, 1.19-2.43). P for trends = 0.01 and 0.003 for melanoma and SCC, respectively.
