Testicular cancer is a cancer that develops in the testicles. In the United States, between 7,500 and 8,000 diagnoses of testicular cancer are made each year, with a man's lifetime risk being roughly 1 in 250.
In 2015, a polygenic risk score including 4 new testicular cancer SNPs (or their proxies; all by GWAS) plus 21 previously found ones concluded that 1% of men scoring in the highest risk category had a 10-fold higher risk of testicular cancer, "although that still adds up to only around a 5 percent (one in 20) chance of developing testicular cancer" over one's life, according to the senior author.[PMID 26503584] The 25 SNPs used in this score (and the associated candidate gene) were:
Other SNPs which may increase (or decrease) risk for testicular cancer include:
- rs3782179 and rs4474514, in the c-kit ligand KITLG gene
- rs4324715 and rs6897876, near the SPRY4 gene
SNPs which may affect the success of chemotherapeutic treatment for testicular cancer include: