DRD2 encodes the Dopamine receptor D2, a target of various psychotropic agents, connected to memory and behavior.
SNPs in include:
- rs1801028, linked to schizophrenia
- rs1076560, linked to alcoholism
- rs1800497, linked to several neuropsychiatric disorders and drugs
- rs4648317, linked to nicotine dependence
[PMID 18063800] Genetically determined differences in learning from errors.
 Compared with DRD2 A1 carriers, subjects homozygous for the DRD2 A2 allele performed poorer in a measure of general cognitive functioning (MMSE) and in long term verbal memory. Our findings suggest that among the aged with cognitive impairments, the homozygous status for the A2 allele of the DRD2 Taq I polymorphism is associated with diminished cognitive performance and increased atrophy in the striatum.