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rs10938397

From SNPedia

Orientationplus
Stabilizedplus
Make rs10938397(A;A)
Make rs10938397(A;G)
Make rs10938397(G;G)
ReferenceGRCh38 38.1/141
Chromosome4
Position45180510
is asnp
is mentioned by
dbSNPrs10938397
ebirs10938397
HLIrs10938397
Exacrs10938397
Varsomers10938397
Maprs10938397
PheGenIrs10938397
hapmaprs10938397
1000 genomesrs10938397
hgdprs10938397
ensemblrs10938397
gopubmedrs10938397
geneviewrs10938397
scholarrs10938397
googlers10938397
pharmgkbrs10938397
gwascentralrs10938397
openSNPrs10938397
23andMers10938397
23andMe allrs10938397
SNP Nexus

SNPshotrs10938397
SNPdbers10938397
MSV3drs10938397
GWAS Ctlgrs10938397
GMAF0.3453
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 19164386OA-icon.png] obesity and type-2 diabetes
GWAS snp
PMID [PMID 19079261OA-icon.png]
Trait Body mass index
Title Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Risk Allele G
P-val 3E-16
Odds Ratio 0.19 [0.13-0.25] kg/m2


[PMID 20061430] Obesity Susceptibility Genetic Variants Identified from Recent Genome-Wide Association Studies: Implications in a Chinese Population

OMIM613222
DescGLUCOSAMINE-6-PHOSPHATE DEAMINASE 2; GNPDA2
Variant
Relatedalso
GWAS snp
PMID [PMID 20935630OA-icon.png]
Trait
Title Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Risk Allele G
P-val 4E-31
Odds Ratio 0.18 [0.14-0.22] kg/m2 increase

[PMID 20843981OA-icon.png] Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children

OMIM601665
Desc
Variant
Relatedalso


[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area


[PMID 21912638OA-icon.png] Studies of metabolic phenotypic correlates of 15 obesity associated gene variants


[PMID 22083549] Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty

[PMID 19478790OA-icon.png] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.

[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

[PMID 19553259OA-icon.png] Common body mass index-associated variants confer risk of extreme obesity.

[PMID 19910641OA-icon.png] Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus.

[PMID 19910938] Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.

[PMID 20127379OA-icon.png] From monogenic to polygenic obesity: recent advances.

[PMID 20520848OA-icon.png] Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.

[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

[PMID 20816195OA-icon.png] Analyses of shared genetic factors between asthma and obesity in children.

[PMID 20824172OA-icon.png] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.

[PMID 21147891] Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study.

[PMID 21283731OA-icon.png] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

[PMID 21593506OA-icon.png] Maternal and offspring adiposity-related genetic variants and gestational weight gain.

[PMID 22179955OA-icon.png] Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.


GET Evidence
rs10938397
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.320312
summary



[PMID 23431394OA-icon.png] Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in chinese han population independently of body mass index


[PMID 23424664OA-icon.png] Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children


[PMID 24269186] An obesity genetic risk score is associated with metabolic syndrome in Chinese children

GWAS snp
PMID [PMID 23563607OA-icon.png]
Trait Body mass index
Title Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Risk Allele G
P-val 2E-13
Odds Ratio 1.16 [NR]


[PMID 23471855OA-icon.png] The genetics of childhood obesity and interaction with dietary macronutrients.


[PMID 23533005] Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder.


[PMID 23588626] Associations of obesity susceptibility loci with hypertension in Chinese children.


[PMID 25093408OA-icon.png] Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population


[PMID 25492288] [Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood]