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rs1360780

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) 2 1.3x increased risk for depression
(T;T) 2.1 1.3x increased risk for depression
ReferenceGRCh38 38.1/141
Chromosome6
Position35639794
GeneFKBP5
is asnp
is mentioned by
dbSNPrs1360780
ebirs1360780
HLIrs1360780
Exacrs1360780
Varsomers1360780
Maprs1360780
PheGenIrs1360780
hapmaprs1360780
1000 genomesrs1360780
hgdprs1360780
ensemblrs1360780
gopubmedrs1360780
geneviewrs1360780
scholarrs1360780
googlers1360780
pharmgkbrs1360780
gwascentralrs1360780
openSNPrs1360780
23andMers1360780
23andMe allrs1360780
SNP Nexus

SNPshotrs1360780
SNPdbers1360780
MSV3drs1360780
GWAS Ctlgrs1360780
GMAF0.2994
Max Magnitude2.1
? (C;C) (C;T) (T;T) 28

In Caucasian non-Hispanics, the rs1360780(T) allele is associated with increased risk for depression, with an odds ratio of 1.39 (CI: 1.14-1.70, p=0.046).[PMID 18191112OA-icon.png]

This same SNP, which is in the FKBP5 gene, may influence how patients respond to antidepressants including citalopram. rs1360780(T;T) homozgyotes tend to report more depressive episodes, but they also respond better to treatment with antidepressants.[PMID 15565110]

[PMID 18349090OA-icon.png] rs9296158 rs3800373 rs1360780 rs9470080 linked with the severity of child abuse to predict level of adult PTSD symptoms after correcting for multiple testing.

OMIM602623
DescFK506-BINDING PROTEIN 5; FKBP5
Variant
Relatedalso
[PMID 19924111OA-icon.png] Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment



[PMID 20090668OA-icon.png] Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide

[PMID 19233472] Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection


[PMID 20008943OA-icon.png] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study


[PMID 20393453OA-icon.png] Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder

[PMID 20547006] FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction

[PMID 20709156] Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders

OMIM602623
Desc
Variant0001
Relatedalso
[PMID 21654733OA-icon.png] Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population


[PMID 22134958] Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients


[PMID 21788965] Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms.


[PMID 22825419] FK506-binding protein 51 (FKBP5) gene polymorphism is not associated with glucocorticoid therapy outcome in patients with idiopathic thrombocytopenic purpura


[PMID 15637659OA-icon.png] Linkage disequilibrium patterns and tagSNP transferability among European populations.


[PMID 17081296OA-icon.png] Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits.


[PMID 18702710] Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.


[PMID 18803430OA-icon.png] Pharmacogenetics of major depression: insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial.


[PMID 19199039OA-icon.png] Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder.


[PMID 19455174OA-icon.png] Psychobiology and molecular genetics of resilience.


[PMID 19676097OA-icon.png] FKBP5 polymorphisms and antidepressant response in geriatric depression.


[PMID 20226536] Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.


[PMID 20726698OA-icon.png] Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals.


[PMID 20849924] Association study between a functional polymorphism of FK506-binding protein 51 (FKBP5) gene and personality traits in healthy subjects.


[PMID 21112363] Association of FKBP5 gene haplotypes with completed suicide in the Japanese population.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21316860OA-icon.png] Genetics of cortisol secretion and depressive symptoms: a candidate gene and genome wide association approach.


[PMID 21449676] Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample.


[PMID 22213790OA-icon.png] Interaction between FKBP5 and childhood trauma and risk of aggressive behavior.


[PMID 22979952OA-icon.png] FKBP5 AND EMOTIONAL NEGLECT INTERACT TO PREDICT INDIVIDUAL DIFFERENCES IN AMYGDALA REACTIVITY


GET Evidence
rs1360780
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.640625
summary



[PMID 22781842OA-icon.png] Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior


[PMID 24253961OA-icon.png] FKBP5 Genotype and Structural Integrity of the Posterior Cingulum


[PMID 22459275] FKBP5 polymorphisms as vulnerability to anxiety and depression in patients with advanced gastric cancer: a controlled and prospective study.


[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.


[PMID 24766650OA-icon.png] Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans


[PMID 24845178OA-icon.png] Stress-related genes and heroin addiction: A role for a functional FKBP5 haplotype


[PMID 24856550] FKBP5 polymorphism is associated with major depression but not with bipolar disorder


[PMID 25088286] Association between the common functional FKBP5 variant (rs1360780) and brain structure in a non-clinical population


[PMID 25115650OA-icon.png] Placental FKBP5 Genetic and Epigenetic Variation Is Associated with Infant Neurobehavioral Outcomes in the RICHS Cohort


[PMID 27078785] FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study


[PMID 27648526] The influence of FKBP5 genotype on expression of FKBP5 and other glucocorticoid-regulated genes, dependent on trauma exposure.