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From SNPedia

Geno Mag Summary
(A;A) 1 higher adiponectin levels
(A;G) if obese, dieting more effective
(G;G) 1 increased risk of insulin resistance
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs17300539
1000 genomesrs17300539
GWAS Ctlgrs17300539
Max Magnitude1
? (A;A) (A;G) (G;G) 28

rs17300539, also known as -11391 G/A, is a SNP in the promoter of the adiponectin ADIPOQ gene.

A small study of 180 Spanish patients with obesity concluded that rs17300539(G;G) individuals are at increased risk of insulin resistance and MetS complications compared to carriers of an (A) allele. The rs17300539(A) allele confered protection from weight regain, particularly at 32-60 weeks after the low-calorie dietary intervention, when improvement in GG subjects had disappeared [PMID 18949681]

[PMID 18776141OA-icon.png] A 2008 article showed higher adiponectin levels with rs17300539 (Minor A is risk allele) with strong significance P(n) = 2.6 x 10(-8) and rs822387 (Minor C allele ) wth a stronger significance of (P(n) = 3.8 x 10(-5), but neither SNP was associated with diabetes risk.

[PMID 19893502] Early Detrimental Metabolic Outcomes of rs17300539-A Allele of ADIPOQ Gene Despite Higher Adiponectinemia

[PMID 20067957OA-icon.png] The genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome related traits

[PMID 19761474OA-icon.png] Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic White Caucasians from Italy: evidence from a family-based study

[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population

[PMID 21208676] Association of the adiponectin rs266729 C>G variant and coronary heart disease in the low risk 'Golden Years' type 1 diabetes cohort


[PMID 20395949OA-icon.png] Variants in the adiponectin gene and serum adiponectin: the Coronary Artery Development in Young Adults (CARDIA) Study

[PMID 21562092OA-icon.png] Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome

[PMID 22459242] Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects

[PMID 18498634OA-icon.png] The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

[PMID 18523726OA-icon.png] Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.

[PMID 18716158OA-icon.png] Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.

[PMID 18827209OA-icon.png] Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.

[PMID 18974768] The adiponectin rs17300539 G>A variant and nephropathy risk.

[PMID 19037660OA-icon.png] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.

[PMID 19056609OA-icon.png] Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy.

[PMID 19074982OA-icon.png] Functional characterization of promoter variants of the adiponectin gene complemented by epidemiological data.

[PMID 19238139OA-icon.png] ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.

[PMID 19543786] ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity.

[PMID 20667095OA-icon.png] Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus.

[PMID 21219602OA-icon.png] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.

[PMID 21229348] Relationship between ADIPOQ gene, circulating high molecular weight adiponectin and albuminuria in individuals with normal kidney function: evidence from a family-based study.

[PMID 21377959] [Association between single nucleotide polymorphisms (SNPs) at the promoter of adiponectin gene and essential hypertension in Chinese Korean and Han of Yanbian region].

[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.

[PMID 21638131] Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.

[PMID 23653335] AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study

[PMID 23658423] Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals

[PMID 23803590] Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia

[PMID 23845780] Association of Adiponectin Promoter Variants With Traits and Clusters of Metabolic Syndrome in Arabs: Family-based study

[PMID 24055485] Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population

[PMID 23102667OA-icon.png] Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study.

[PMID 23274890OA-icon.png] Evidence of a causal relationship between adiponectin levels and insulin sensitivity: a Mendelian randomization study.

[PMID 25223469] Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis

[PMID 26887769] [Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].

[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.

[PMID 28060790OA-icon.png] Family-Based Association Study of rs17300539 and rs12495941 Polymorphism in Adiponectin Gene and Polycystic Ovary Syndrome in a Chinese Population.

[PMID 31565221OA-icon.png] Levels of nitric oxide metabolites, adiponectin and endothelin are associated with SNPs of the adiponectin and endothelin genes.

[PMID 33562295OA-icon.png] Circulating Adiponectin and Its Association with Metabolic Traits and Type 2 Diabetes: Gene-Diet Interactions Focusing on Selected Gene Variants and at the Genome-Wide Level in High-Cardiovascular Risk Mediterranean Subjects.