rs2074190
From SNPedia
Orientation | minus |
Stabilized | minus |
Geno | Mag | Summary |
---|---|---|
(C;C) | 2.2x risk for AIA | |
(C;T) | 2.2x risk for AIA | |
(T;T) | 0 | common |
Reference | GRCh38 38.1/142 |
Chromosome | 17 |
Position | 47733844 |
Gene | TBX21 |
is a | snp |
is | mentioned by |
dbSNP | rs2074190 |
dbSNP (classic) | rs2074190 |
ClinGen | rs2074190 |
ebi | rs2074190 |
HLI | rs2074190 |
Exac | rs2074190 |
Gnomad | rs2074190 |
Varsome | rs2074190 |
LitVar | rs2074190 |
Map | rs2074190 |
PheGenI | rs2074190 |
Biobank | rs2074190 |
1000 genomes | rs2074190 |
hgdp | rs2074190 |
ensembl | rs2074190 |
geneview | rs2074190 |
scholar | rs2074190 |
rs2074190 | |
pharmgkb | rs2074190 |
gwascentral | rs2074190 |
openSNP | rs2074190 |
23andMe | rs2074190 |
SNPshot | rs2074190 |
SNPdbe | rs2074190 |
MSV3d | rs2074190 |
GWAS Ctlg | rs2074190 |
GMAF | 0.2401 |
Max Magnitude | 0 |
? | (C;C) (C;T) (T;T) | 28 |
---|---|---|
|
rs2074190(G;G) and rs2074190(A;G) genotypes for the TBX21 gene are calculated to be at 2.19 fold higher risk (CI: 1.27-3.77) for aspirin-induced asthma (AIA) compared to rs2074190(A;A) homozygotes, based on a study of 72 patients vs 640 controls in a study of a Japanese population. [PMID 15806396]
Note that in this population, but perhaps not others, linkage disequilibrium exists between this SNP located in the first exon, rs2074190, and a SNP located upstream of the gene, rs4794067, with a predictive accuracy of 92%.