|(A;A)||1.8||in prostrate cancer patients, this is statistically associated with a somewhat more aggressive cancer|
|(A;G)||1.6||in prostrate cancer patients, this is statistically associated with a somewhat more aggressive cancer|
[PMID 25274378] A study of ~1,800 Caucasian prostate cancer patients concludes that the rs2735839(A) allele is associated with aggressive prostate cancer in general, and more specifically, in Gleason score 7 patients, it is more often associated with being GS 4 + 3 rather than GS 3 + 4 (odd ratio 1.85, CI: 1.31-2.61).
- the haplotype rs6983267 rs1016343 rs4242384
[PMID 19366831] Genotyping 13 SNPs (including this one) in 1,308 Caucasian prostate cancer patients led to the conclusion that while none of the SNP associations were as significant as having a first-degree family history of the disease, they did replicate. And in fact, for rs2735839, the risk estimate varied by family history.
[PMID 19336566] Replication of the 10q11 and Xp11 Prostate Cancer Risk Variants: Results from a Utah Pedigree-Based Study.
[PMID 19902474] Replication of prostate cancer risk loci on 8q24, 11q13, 17q12, 19q33, and Xp11 in African Americans
[PMID 20460480] Susceptibility loci associated with prostate cancer progression and mortality
[PMID 21465221] Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript
[PMID 21390317] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3
[PMID 22549899] Genetic polymorphism and prostate cancer aggressiveness: A case-only study of 1,536 GWAS and candidate SNPs in African-Americans and European-Americans
[PMID 18708398] Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium.
[PMID 18794092] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
[PMID 18974127] Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.
[PMID 19104501] Prostate cancer genomics: towards a new understanding.
[PMID 19153072] Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk.
[PMID 19318432] Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
[PMID 19318570] A novel prostate cancer susceptibility locus at 19q13.
[PMID 19434657] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
[PMID 19505914] Two independent prostate cancer risk-associated Loci at 11q13.
[PMID 19549807] Prostate cancer risk associated loci in African Americans.
[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
[PMID 19823874] A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.
[PMID 20039378] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.
[PMID 21318478] Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels.
[PMID 21367958] Association of prostate cancer risk Loci with disease aggressiveness and prostate cancer-specific mortality.
[PMID 21538423] Early onset prostate cancer has a significant genetic component.
|Trait||Prostate-specific antigen levels|
|Title||Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.|
|Odds Ratio||.19 [NR] % higher levels|
[PMID 24411283] Prostate Cancer (PCa) Risk Variants and Risk of Fatal PCa in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
[PMID 22901566] Effectiveness of the combined evaluation of KLK3 genetics and free-to-total prostate specific antigen ratio for prostate cancer diagnosis.
[PMID 23543094] Testing for associations between loci and environmental gradients using latent factor mixed models.
[PMID 25715684] Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases