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rs445925(T;T)

From SNPedia
APOE E2/E2 most likely; lower Alzheimer's risk
Is agenotype
ofrs445925
GeneAPOC1
Chromosome19
Position44,912,383
mentionedby
Magnitude4
ReputeGood
Geno Mag Summary
(C;C) 0 common/normal
(T;T) 4 APOE E2/E2 most likely; lower Alzheimer's risk

Likely to have 2 copies of the ApoE2 allele, as long as rs7412 is not (C;C) or (C;T), and the lowest risk of Alzheimer's disease (among ApoE genotypes). Based on a statistical correlation in some populations; see discussion at rs445925. Presence of gs268 confirms E2/E2 status if present; most other ApoE genosets (such as gs270 or gs216) take precedence for establishing ApoE allele status over this rs445925 prediction if present.