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rs4148739

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 2 7x less likely to respond to certain antidepressants
(A;G) 1 7x more likely to respond to certain antidepressants
(G;G) 1 7x more likely to respond to certain antidepressants
ReferenceGRCh38 38.1/141
Chromosome7
Position87531733
GeneABCB1
is asnp
is mentioned by
dbSNPrs4148739
ebirs4148739
HLIrs4148739
Exacrs4148739
Varsomers4148739
Maprs4148739
PheGenIrs4148739
hapmaprs4148739
1000 genomesrs4148739
hgdprs4148739
ensemblrs4148739
gopubmedrs4148739
geneviewrs4148739
scholarrs4148739
googlers4148739
pharmgkbrs4148739
gwascentralrs4148739
openSNPrs4148739
23andMers4148739
23andMe allrs4148739
SNP Nexus

SNPshotrs4148739
SNPdbers4148739
MSV3drs4148739
GWAS Ctlgrs4148739
GMAF0.1318
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs4148739 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs4148739 is one of 9 SNPs found within a tight linkage block (r2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below.

When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are known to be substrates include citalopram, paroxetine, amitriptyline, and venlafaxine. The relative odds of better response for rs4148739(G) carriers is 7.72 (CI: 2.8-21.3, p=0.000065) based on a study of ~400 primarily Caucasian patients.10.1016/j.neuron.2007.11.017

The 9 SNPs in the linkage block identified are 10.1016/j.neuron.2007.11.017:

Neighborrs2032582
Distance431
Neighborrs11983225
Distance471



GET Evidence
rs4148739
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.148438
summary



[PMID 24192121] ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients