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rs4148740

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 7x more likely to respond to certain antidepressants
(C;T) 7x more likely to respond to certain antidepressants
(T;T) 7x less likely to respond to certain antidepressants
ReferenceGRCh38 38.1/141
Chromosome7
Position87522787
GeneABCB1
is asnp
is mentioned by
dbSNPrs4148740
ebirs4148740
HLIrs4148740
Exacrs4148740
Varsomers4148740
Maprs4148740
PheGenIrs4148740
hapmaprs4148740
1000 genomesrs4148740
hgdprs4148740
ensemblrs4148740
gopubmedrs4148740
geneviewrs4148740
scholarrs4148740
googlers4148740
pharmgkbrs4148740
gwascentralrs4148740
openSNPrs4148740
23andMers4148740
23andMe allrs4148740
SNP Nexus

SNPshotrs4148740
SNPdbers4148740
MSV3drs4148740
GWAS Ctlgrs4148740
GMAF0.1299
Max Magnitude
? (C;C) (C;T) (T;T) 28
rs4148740 is a SNP in the ABCB1 gene (also known as the MDR1 gene), which encodes a protein that transports certain molecules across the blood-brain barrier. SNPs in ABCB1 may thus influence the intracerebral concentrations of certain drugs and thus their efficacy or potential for adverse side effects. rs4148740 is one of 9 SNPs found within a tight linkage block (r2 >= 0.8 ) such that the minor allele at any one of them predicts (with ~80%+ accuracy) that the other SNPs will also be the minor allele. The list of the 9 SNPs is shown below.

When treated for depression with substrates of the protein encoded by ABCB1, carriers of one or two minor alleles at these ABCB1 SNPs have been reported to respond better than non-carriers. The antidepressant drugs that are known to be substrates include citalopram, paroxetine, amitriptyline, and venlafaxine. The relative odds of better response for rs4148740(T) carriers is 7.72 (CI: 2.8-21.3, p=0.000065) based on a study of ~400 primarily Caucasian patients.10.1016/j.neuron.2007.11.017

The 9 SNPs in the linkage block identified are 10.1016/j.neuron.2007.11.017:



[PMID 15197162OA-icon.png] Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene.


GET Evidence
rs4148740
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.148438
summary