Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is a neuropsychiatric disorder with high heritability (~70%) characterized by significant problems with executive functioning. Wikipedia NIMH
A 2016 review and meta-analysis of genetic, pharmacogenetic and biochemical studies on ADHD in adults concluded that an association was seen for the BAIAP2 gene, but no other genetic, pharmacogenetic or biochemical association was found to be significantly associated.[PMID 27217152
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As of 2012, more than 1,800 publications dealing with ADHD genetics have been published, but unfortunately, no significant major genes have been identified and results are mainly inconclusive. Furthermore, the SNPs found by GWAS studies explain only a small part of the genetic variance.[PMID 23090882]
A 2009 meta-analysis of 75 separate studies found no association between ADHD and SNPs in the SLC6A4 or HTR1B genes. [PMID 19721846]
Many genes have been reported to influence susceptibility to ADHD, however slightly, and some may also affect the risk of substance abuse disorders. [PMID 18821565]
