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Magnitude

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(Redirected from Help (magnitude))

See also Max Magnitude, Genotype, Genoset and Repute and Promethease/Learn_More

Magnitude is a subjective measure of interest varying from 0 to 10. Over time it should be adjusted up or down by the community. It is generally interpreted as follows...

Magnitude Description
0 You have the common genotype, for which nothing interesting is known.
0.1 You have the common genotype, but its interesting that this varies for others
1 Semi-plausible but not very exciting
(blank) No one has yet assigned a magnitude. Treated as a 1.
2 looks interesting enough to be worth reading
2.1 hmm, interesting
3 Probably worth your time
4 Male/Female sex calls, used for QC, anything above this is definitely something you should pay attention to
10 Really significant information!

Numbers bigger than 10 are allowed and expected in the future. Since User:Watson and User:Steven Pinker requested not to learn their APOE4 gs216 status that serves as useful a landmark in the scale. Several rare genotypes are higher magnitude. The genotypes with highest magnitude are

 MagnitudeReputeSummary
rs137852690(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs786205451(A;A)9.1BadEpidermolysis bullosa (predicted)
rs104894089(A;A)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894085(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs387907235(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894090(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894087(A;A)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894086(A;A)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs104894086(T;T)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
rs137852689(C;C)9.1BadLipoid congenital adrenal hyperplasia (LCAH); treatment required
... further results

The genosets with the highest magnitude are

 MagnitudeReputeSummary
Gs14910Testing for orientation issues
Gs31810BadUnsupported platform
Gs3037WeGene quality control issues.
Gs3007Data Quality issue. Your data provider is reporting heterozygosity on the Y chromosome.
Gs3066.5BadPoor metabolizer of fluoropyrimidines (e.g. 5-fluorouracil, capecitabine or tegafur).
Gs2286BadSickle cell affected
Gs2676APOE1/APOE1
Gs2166Bad2 copies of the APOE-ε4 allele
Gs3146BadMUTYH-associated polyposis (and colon cancer risk)
Gs3125.5BadIntermediate metabolizer of fluoropyrimidines (such as 5-fluorouracil and capecitabine).
... further results

See also the related concept Repute.