See also Max Magnitude, Genotype, Genoset and Repute and Promethease/Learn_More
Magnitude is a subjective measure of interest varying from 0 to 10. Over time it should be adjusted up or down by the community. It is generally interpreted as follows...
| Magnitude | Description |
|---|---|
| 0 | You have the common genotype, for which nothing interesting is known. |
| 0.1 | You have the common genotype, but its interesting that this varies for others |
| 1 | Semi-plausible but not very exciting |
| (blank) | No one has yet assigned a magnitude. Treated as a 1. |
| 2 | looks interesting enough to be worth reading |
| 2.1 | hmm, interesting |
| 3 | Probably worth your time |
| 4 | Male/Female sex calls, used for QC, anything above this is definitely something you should pay attention to |
| 10 | Really significant information! |
Numbers bigger than 10 are allowed and expected in the future. Since User:Watson and User:Steven Pinker requested not to learn their APOE4 gs216 status that serves as useful a landmark in the scale. Several rare genotypes are higher magnitude. The genotypes with highest magnitude are
| Magnitude | Repute | Summary | |
|---|---|---|---|
| rs1801253(G;G) | 0 | Good | |
| rs1801253(C;C) | 1.1 | responds well to bucindolol; may also depend on rs1801252 | |
| rs17822931(C;C) | 2 | Wet earwax. Normal body odour. Normal colostrum. | |
| rs17822931(T;T) | 2.5 | Good | Dry earwax. No body odour. Likely Asian ancestry. Reduced colostrum. |
| rs16891982(C;C) | 1.1 | Good | generally non-European, but if European, 7x more likely to have black hair |
| rs16891982(G;G) | 1.1 | Generally European; Light skin; Possibly an increased risk of melanoma | |
| rs1426654(A;A) | 2.7 | probably light-skinned, European ancestry | |
| rs1426654(G;G) | 2.6 | probably darker-skinned, Asian or African ancestry | |
| rs351855(C;C) | 0 | Good | normal |
| rs351855(T;T) | 2.9 | Bad | 2x increased prostate cancer risk; among breast cancer patients, herceptin is less effective |
| ... further results | |||
The genosets with the highest magnitude are
| Magnitude | Repute | Summary | |
|---|---|---|---|
| Gs149 | 10 | Testing for orientation issues | |
| Gs318 | 10 | Bad | Unsupported platform |
| Gs303 | 7 | WeGene quality control issues. | |
| Gs300 | 7 | Data Quality issue. Your data provider is reporting heterozygosity on the Y chromosome. | |
| Gs306 | 6.5 | Bad | Poor metabolizer of fluoropyrimidines (e.g. 5-fluorouracil, capecitabine or tegafur). |
| Gs267 | 6 | APOE1/APOE1 | |
| Gs314 | 6 | Bad | MUTYH-associated polyposis (and colon cancer risk) |
| Gs216 | 6 | Bad | 2 copies of the APOE-ε4 allele |
| Gs228 | 6 | Bad | Sickle cell affected |
| Gs312 | 5.5 | Bad | Intermediate metabolizer of fluoropyrimidines (such as 5-fluorouracil and capecitabine). |
| ... further results | |||
See also the related concept Repute.
