Migrane is a type of headache. Understanding of genetics of migraine is proceeding fast, based on GWAS studies and large scale exome-sequencing studies. Among the main logi are TRPM8, PRDM16, and LRP1. This increase of knowledge is opening the door to personalized medicine and better medication as well.
[PMID 29932027] Circulating Biomarkers In Migraine. New Opportunities For Precision Medicine.
[PMID 29478595] Genetics of migraine.
[PMID 27681292] Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
[PMID 27322543] Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
[PMID 27543003] Migraine genetics: from genome-wide association studies to translational insights.
These SNPs have been reported to potentially present increased risk for migraines:
- rs1835740, ch 8q22.1, possibly involved in glutamate metabolism
- rs1043994, a SNP in the NOTCH3 gene
- rs1042838, a SNP in the PGR gene, specifically associated with migraine-associated vertigo
- A 19bp insertion/deletion promoter polymorphism in the DBH gene, which appears to lack a rs# [PMID 17095019]
- rs2651899, ch 1p36.32, PRDM16 gene
- rs10166942, ch 2q37.1, TRPM8 gene
- rs11172113, ch 12q13.3, LRP1 gene
These SNPs may also relate to migraines:
Numerous single studies indicate a correlation between a given SNP and migraines, but subsequent studies, whether of different populations, larger patient numbers, or via pooled meta-analyses, have often failed to replicate the initial findings. Caveat emptor!
Drugs used to treat migraines may also be more or less successful based on a patient's genotype, since SNPs in a variety of genes affect the metabolism of these drugs. Some of the classes of drugs that have been used to treat migraines include the following:
- beta blockers such as metoprolol
- antidepressants, in particular, tricyclic antidepressants such as imipramine
- anticonvulsants such as valproic acid
- calcium channel blockers such as diltiazem
- triptans such as sumatriptan; see rs5443