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From SNPedia
(Redirected from Obesity (extreme))

Obesity, becoming ever more common in modern societies, is often associated with serious health problems such as diabetes and heart disease. Obesity can be caused by a combination of too much food, too little exercise, and genetic susceptibility. Wikipedia Various genes are thought to affect susceptibility to obesity.

  • FTO is also called the fatso gene. Wikipedia
    • rs9939609 is associated with changes in BMI and obesity beginning at age 7.
    • rs1121980 is strongly associated with early onset obesity.
  • SCG3 may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion. [PMID 17094264] In one study, two SNPs affected the transcriptional activity of SCG3, and subjects with the minor allele seemed to be resistant to obesity. [1]

Other SNPs that affect obesity:

  • rs6971091, in an uncharacterized gene on chromosome 7, is associated with more than doubled risk of obesity.

Other topics related to obesity: BMI may not reflect the amount of internal fat. [3]