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rs1859962

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 2.3 1.28x increased risk for prostate cancer
(G;T) 0 normal risk
(T;T) 0 normal risk
ReferenceGRCh38 38.1/141
Chromosome17
Position71112612
GeneCASC17
is asnp
is mentioned by
dbSNPrs1859962
ebirs1859962
HLIrs1859962
Exacrs1859962
Varsomers1859962
Maprs1859962
PheGenIrs1859962
hapmaprs1859962
1000 genomesrs1859962
hgdprs1859962
ensemblrs1859962
gopubmedrs1859962
geneviewrs1859962
scholarrs1859962
googlers1859962
pharmgkbrs1859962
gwascentralrs1859962
openSNPrs1859962
23andMers1859962
23andMe allrs1859962
SNP Nexus

SNPshotrs1859962
SNPdbers1859962
MSV3drs1859962
GWAS Ctlgrs1859962
GMAF0.3976
Max Magnitude2.3
? (G;G) (G;T) (T;T) 28
rs1859962 is a SNP on chromosome 17q24.3, associated with increased risk for prostate cancer in several studies.

In a study of over 3,600 Caucasians with prostate cancer, rs1859962 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On its own, the rs1859962(G;G) risk genotype yields an odds ratio for developing prostate cancer of 1.28 (CI: 1.11-1.47, p=5.5x10e-4) and may account for 6.5% of population attributable risk.10.1056/NEJMoa075819

news linked to Prostate cancer and type-2 diabetes

cancer-genetics these snps influence genetic risk for prostate cancer

GWAS
SNP rs1859962
PubMedID [PMID 17603485]
Condition Prostate cancer
Gene Intergenic
Risk Allele G
pValue 3.00E-010
OR 1.2
95% CI 1.14-1.27


GWAS snp
PMID [PMID 18264097]
Trait Prostate cancer
Title Multiple newly identified loci associated with prostate cancer susceptibility
Risk Allele G
P-val 9.9999999999999995E-7
Odds Ratio 1.26 [NR]
OMIM176807
DescPROSTATE CANCER
Variant
Relatedalso


GWAS snp
PMID [PMID 19767753OA-icon.png]
Trait Prostate cancer
Title Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Risk Allele T
P-val 2E-16
Odds Ratio NR NR


[PMID 21086507] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP)

GWAS snp
PMID [PMID 21743057OA-icon.png]
Trait
Title Genome-wide association study identifies new prostate cancer susceptibility loci.
Risk Allele G
P-val 3E-11
Odds Ratio 1.2700 [1.18-1.37]


[PMID 21959049OA-icon.png] Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population


[PMID 22665440OA-icon.png] Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus


[PMID 18491292OA-icon.png] Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.


[PMID 18701471OA-icon.png] Chromosome 17q12 variants contribute to risk of early-onset prostate cancer.


[PMID 18794092OA-icon.png] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.


[PMID 18974127OA-icon.png] Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.


[PMID 19058137OA-icon.png] Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.


[PMID 19104501OA-icon.png] Prostate cancer genomics: towards a new understanding.


[PMID 19318432OA-icon.png] Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.


[PMID 19366828OA-icon.png] Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.


[PMID 19371897OA-icon.png] Pathological outcomes associated with the 17q prostate cancer risk variants.


[PMID 19434657OA-icon.png] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.


[PMID 19549807OA-icon.png] Prostate cancer risk associated loci in African Americans.


[PMID 19727433OA-icon.png] Cancer genetic association studies in the genome-wide age.


[PMID 20026053] WITHDRAWN: Relationships between 8q24 and 17q risk loci and sporadic or latent prostate cancer and the impacts of these loci on the clinicopathologic characteristics of prostate cancer.


[PMID 20039378OA-icon.png] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.


[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.


[PMID 21390317OA-icon.png] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.


[PMID 21456070OA-icon.png] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP).


[PMID 21538423OA-icon.png] Early onset prostate cancer has a significant genetic component.


[PMID 21557267] A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population.


[PMID 22077888OA-icon.png] Association of prostate cancer risk alleles with unfavourable pathological characteristics in potential candidates for active surveillance.


[PMID 22561070] 8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort().


GET Evidence
rs1859962
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.679688
summary



[PMID 24037955] The presence of prostate cancer at biopsy is predicted by a number of genetic variants