Gestational diabetes
From SNPedia
Gestational diabetes (or gestational diabetes mellitus, GDM) is a treatable medical condition in which non-diabetic women exhibit high blood glucose levels during pregnancy. GDM affects 3-10% of pregnancies, placing the mothers at increased risk of developing type-2 diabetes after pregnancy, and increasing the odds that their offspring will be prone to childhood obesity and type-2 diabetes later in life. Wikipedia
Several studies have reported that numerous SNPs previously shown in large studies to be associated with increased risk for type-2 diabetes can also be shown to be associated with increased risk for gestational diabetes. Specific SNPs confirmed in such studies include:
- rs7756992, rs7756992, rs10440833 and rs7754840 in the CDKAL1 gene
- rs10811661 and rs10965250 in the CDKN2A-CDKN2B region
- rs1111875, rs5015480 and rs7923837 in the HHEX gene
- rs7903146 in the TCF7L2 gene
- rs13266634 and rs3802177 in the SLC30A8 gene
- rs4402960, rs1470579 in the IGF2BP2 gene
- rs7501939 in the HNF1B gene
- rs10010131 in the WFS1 gene
- rs1801282 in the PPARG gene
- rs5219 in the KCNJ11 gene
- rs9939609 in the FTO gene
- rs163184 in the KCNQ1 gene
- rs1552224 in the ARAP1 gene
- rs1387153 in the MTNR1B gene
Studies reporting these associations include:
- [PMID 19002430] studying 869 Korean women with GDM and 345 female and 287 male Korean non-diabetic controls
- [PMID 18984664] analyzing a cohort of Danish women with a history of GDM (n=283) and in glucose tolerant women of the population-based Inter99 cohort (n=2,446)
- [PMID 22233651] analyzing a cohort of 468 Korean women with GDM and 1242 nondiabetic control women
