PGx-Passport
From SNPedia
With a stated mission of providing "effective treatment optimization accessible to every European citizen", the Ubiquitous Pharmacogenomics Consortium (upgx.eu) has published a "PGx-Passport", consisting of 58 variants in 14 important pharmocogenomic genes. In combination with the Dutch Pharmacogenetics Working Group (DPWG) guidelines, the PGx-Passport is designed to optimize prescribing for 49 common drugs.[PMID 31038729]
The details for the PGx-Passport are presented below in two tables; the first shows the specific SNPs, and the second the drug for which corresponding actionable DPWG guidelines are available.
| Gene | Defining rsID | Allele | Function |
|---|---|---|---|
| CYP2B6 | rs2279343, rs3745274 | *6 | Decreased or none |
| CYP2B6 | rs3745274 | *9 | Decreased or none |
| CYP2B6 | rs2279343 | *4 | Decreased or none |
| CYP2B6 | rs2279343, rs28399499 | *16 | Decreased or none |
| CYP2B6 | rs28399499 | *18 | Decreased or none |
| CYP2B6 | rs3211371 | *5 | Decreased or full |
| CYP2C9 | rs1799853 | *2 | Decreased |
| CYP2C9 | rs1057910 | *3 | Decreased |
| CYP2C9 | rs28371686 | *5 | Decreased |
| CYP2C9 | rs28371685 | *11 | Decreased |
| CYP2C19 | rs4244285 | *2 | None |
| CYP2C19 | rs4986893 | *3 | None |
| CYP2C19 | rs28399504 | *4A/B | None |
| CYP2C19 | rs56337013 | *5 | None |
| CYP2C19 | rs72552267 | *6 | None |
| CYP2C19 | rs41291556 | *8 | Decreased or none |
| CYP2C19 | rs17884712 | *9 | Decreased |
| CYP2C19 | rs6413438 | *10 | Decreased |
| CYP2C19 | rs12248560 | *17 | Increased |
| CYP2D6 | n/a | *xN (gene duplication) | Increased |
| CYP2D6 | rs35742686 | *3 | None |
| CYP2D6 | rs3892097, (rs1065852) | *4 | None |
| CYP2D6 | n/a | *5 | None (gene deletion) |
| CYP2D6 | rs5030655 | *6 | None |
| CYP2D6 | rs5030865 | *8 | None |
| CYP2D6 | rs5030656 | *9 | Decreased |
| CYP2D6 | rs1065852 | *10 | Decreased |
| CYP2D6 | rs5030865, rs1065852 | *14A | Decreased |
| CYP2D6 | rs5030865 | *14B | Decreased |
| CYP2D6 | rs28371706 | *17 | Decreased |
| CYP2D6 | rs28371725 | *41 | Decreased |
| CYP3A5 | rs776746 | *3 | None |
| CYP3A5 | rs10264272 | *6 | None |
| CYP3A5 | rs41303343 | *7 | None |
| DPYD | rs3918290 | *2A | None |
| DPYD | rs55886062 | *13 | None |
| DPYD | rs67376798 | X | Decreased |
| DPYD | rs56038477 | X | Decreased |
| F5 | rs6025 | X | Decreased |
| HLA-A | rs1061235 | *31:01 | High-risk allele |
| HLA-B | rs3909184, rs2844682 | *15:02 | High-risk allele |
| HLA-B | rs2395029 | *57:01 | High-risk allele |
| NUDT15 | rs746071566, rs116855232 | *2 | Decreased |
| NUDT15 | rs116855232 | *3 | Decreased |
| NUDT15 | rs746071566 | *6 | Decreased |
| NUDT15 | rs746071566 | *9 | Decreased |
| SLCO1B1 | rs4149056 | *5/*15/*17 | Decreased |
| TPMT | rs1800462 | *2 | None |
| TPMT | rs1142345, rs1800460 | *3A | None |
| TPMT | rs1800460 | *3B | None |
| TPMT | rs1142345 | *3C | None |
| UGT1A1 | rs4148323 | *6 | Decreased |
| UGT1A1 | rs35350960 | *27 | Decreased |
| UGT1A1 | rs8175347 | *28 | Decreased |
| UGT1A1 | rs8175347 | *37 | Decreased |
| VKORC1 | rs9934438 | X | Decreased expression |
