| less IL6; certain risks, see details |
| Geno
|
Mag
|
Summary
|
| (C;C)
|
2
|
less IL6; certain risks, see details
|
| (C;G)
|
|
complex; see details
|
| (G;G)
|
2
|
more IL6; certain risks, see details
|
rs1800795 is a SNP in the promoter of the interleukin-6 IL6 gene, affecting the levels made of this important cytokine. The (C;C) genotype is found almost exclusively in the caucasian populations. It was first described in 1998, when it was shown that the rs1800795(C) allele produces less IL6 than the (G) allele, which supported the hypothesis that a protective genotype against systemic onset juvenile rheumatoid arthritis would be rs1800795(C;C), and indeed, few juvenile RA patients had that genotype.[PMID 9769329]
The [rs1800795]](C) allele, generally associated with lower levels of IL6, has been associated with increased risk in these studies:
- rs1800795 (C;C) and (C;G) Caucasians who are excessively heavy (body mass index ~33 +/- 5kg/m2) are at increased risk (odds ratio 5.2, p=0.003) for developing obesity-related metabolic disorders such as hypertension, atherogenic dyslipidemia, and insulin resistance.[PMID 17998015]
- A study of 238 Caucasians with type-2 diabetes concluded that [[rs1800795](C) carriers have an insulin resistance "IL-6-sensitive" phenotype and perhaps strategies to manage insulin resistance should be different between (C) carriers vs. (G;G) patients.[PMID 16140413]
- In patients with end-stage renal disease (ESRD) being treated by hemodialysis, rs1800795(C) allele carriers had higher diastolic blood pressure (p=0.008) and a higher left ventricular mass index (p=0.026) than (G;G) homozygotes. Among diabetic patients in dialysis, the prevalence of left ventricular hypertrophy in (C) allele carriers was 87.5% vs. 36.3% among (G;G) genotypes (p= 0.02).[PMID 12846758]
- Among recipient of a kidney transplant, rs1800795(C) allele carriers had worse three-year graft survival (71/104 = 68.3%; p=0.0059) with a 3.7-fold increased relative risk of graft loss compared to rs1800795(G;G) genotypes (48/54 = 88.9%). The authors suggest that determining the rs1800795 genotype may offer a new method for identifying patients at increased risk of allograft loss.[PMID 12371985]
- Although the rs1800795(C) allele was not associated with a higher frequency of heart attacks, it did have an association with inflammation and infarcts detectable only by MRI, suggesting that rs1800795(C) may chronically predispose an individual to develop atherosclerosis.[PMID 12482836]
- The combination of carrying at least one rs1800795(C) and one rs1205(T), a SNP in the C-reactive protein gene, led to higher risk of a stroke after cardiac surgery (odds ratio 3.3, CI: 1.4-8.1, p=0.0023) compared to individuals who were rs1800795(G;G) and rs1205(C;C).[PMID 16051899]
- The rs1800795(C) allele was associated with higher postoperative IL6 levels and a less favorable clinical outcome following coronary revascularization surgery.[PMID 16183563]
- The rs1800795(C;C) genotype was significantly higher in the group of 122 adult periodontitis patients than in controls (odds ratio 1.896, CI: 1.1-3.2, p=0.0283).[PMID 17209781]
